Impact of HIV and HIV with HBV co-infection on hepatic transaminases and CD4+ T cell counts in Sokoto, North Western Nigeria
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 2
Abstract
Human immunodeficiency virus (HIV) and Hepatitis B (HBV) virus co-infection is not unexpected because both infections have common routes of transmission. The former increases morbidity and mortality of HBV liver related diseases. Alanine aminotransferase (ALT) and Asphatate aminotransferase (AST) are enzymes that reflect integrity of liver cells and whose elevation in the blood indicate liver cell injury. The CD4+ T cells which are often depleted and malfunctioned in HIV infection play a central role in the immunology of HBV infection. This study aimed at determining impact of HIV and HIV with HBV co-infection on Hepatic transaminases and CD4+ T cell counts. A cross-sectional design was adopted, in which 180 treatment naïve HIV infected adults attending HIV clinics at Usmanu Danfodiyo University Teaching Hospital, Sokoto (UDUTH) and Specialist Hospital Sokoto (SHS), were recruited in the study from March 2014 to October 2015. Alanine aminotransferase and asphatate aminotransferase levels, CD4+ T cell counts, and HBsAg were evaluated. The prevalence of HBsAg among HIV infected patients was higher among male participants compared to female participants (P=0.016). Mean ALT and AST levels were higher in males compared to females among the study participants (P<0.077; 0.044 respectively). Mean CD4+ T cell counts were significantly higher among female study participants than in male study participants (P= 0.0001). The mean CD4+ T cell counts, ALT and AST levels were higher among patients with HIV and HBV co-infection compared to HIV monoinfected patients (P< 0.022; 0.854; 0.341 respectively). Prevalence of elevated ALT and AST levels were higher among patients with HIV and HBV co-infection than in patients with HIV mono-infection (P< 0.323: 0.074 respectively). Severely immunosuppressed individuals irrespective of Hepatitis B co-infection were more likely to have either higher mean or elevated ALT and AST levels. Baseline ALT, AST levels and HBsAg screening should be ensured in HIV patients. Treatment options for patients with severe immunosuppression in either HIV mono-infection or HIV and HBV co-infection should be carefully considered and monitoring of transaminases be ensured.
Authors and Affiliations
A Yakubu
Keywords
Related Articles
- EP ID EP274126
- DOI -
- Views 52
- Downloads 0
Heterotopic Pregnancy in Natural Conception Cycle
Heterotopic pregnancy is defined as co-existence of intra uterine and extra uterine gestation. The incidence on theoretical basis is estimated to be 1 in 30,000 pregnancies. However more recent data indicates that the ra...
Fatal Headache – A Case Report
Sudden death as a term is used to describe deaths occurring in an apparently healthy individual within 24 hours with or without symptoms. A medicolegal investigation is crucial to identify such deaths and exclude unnatur...
Anaesthetic Management of Scoliotic Deformity with Wilson’s Disease
Wilson’s disease is an inherited autosomal recessive disorder of copper metabolism. As a consequence copper accumulates in liver, brain, kidney and red blood cells. Patients may develop chronic liver disease, hemolytic a...
Hesperidin and Experimentally-Induced Arthritis in Male Rats
Background: Rheumatoid arthritis (RA), the most common cause of arthritis, is a chronic autoimmune disease of multifactorial etiology characterized by synovial hyperplasia, autoantibody production, cartilage and bone des...
Effectiveness of Imparting Education and Giving Demonstration in Small Group of Women for Promotion of Breast Self Examination: An Experience in Rural Areas of Jaipur District, Rajasthan
Effectiveness of imparting education and giving demonstration in small groups of women for promotion of Breast Self Examination: An experiance in rural areas of Jaipur district, Rajasthan. Abstract- Breast cancer is a ma...