Impact of malnutrition on febrile neutropenia in children with acute lymphoblastic leukemia during induction phase chemotherapy
Journal Title: Paediatrica Indonesiana - Year 2018, Vol 58, Issue 6
Abstract
Background Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and adolescents. Febrile Neutropenia (FN) is a medical emergency on ALL that often leads to death. Nutrition status assessment on ALL patient is important because malnutrition can reduce the tolerance of chemotherapy, increase incidence of infection and decrease survival rate. Objectives To assess malnutrition as a risk factor for FN in children with ALL. Methods This case-control study was performed at Sardjito Hospital, Yogyakarta on patients aged 1 month to 18 years diagnosed with ALL and undergoing induction phase chemotherapy between January 2013 and December 2015. The case and control subjects were children with and without FN, respectively. Febrile neutropenia was confirmed by patients temperature above 38ºC at one measurement and a peripheral neutrophil count of less than 1,000/mm3. Malnutrition was defined as body weight-for-height was between -2 and <-3 standard deviation. Subjects were included using simple random sampling. Result Bivariate analysis showed a significant correlation between malnutrition and FN (OR 2.62; 95%CI 1.07 to 6.45; P=0.03). However, there was no inverse correlation between socioeconomic status and FN (OR 1.1; 95%CI 0.42 to 2.41; P=0.83). There was no correlation between nutritional status and duration of FN (P= 0.48). Conclusion Malnutrition is a risk factor for FN in children with acute lymphoblastic leukemia.
Authors and Affiliations
Marshalla Agnes, Pudjo Widjajanto, Wahyu Damayanti
Keywords
Related Articles
- EP ID EP508849
- DOI 10.14238/pi58.6.2018.298-304
- Views 75
- Downloads 0
Duration of watching TV and child language development in young children
Background Many factors contribute to language development in children. About 5-8% of children in Indonesia experience delayed language skills. Young children need appropriate stimulation for optimal development. Childre...
Diabetes duration and thyroid stimulating hormone levels in children with type 1 diabetes mellitus
Background Children with type 1 diabetes mellitus (T1DM) are at risk of thyroid dysfunction. An association between diabetes duration and thyroid stimulating hormone level remains inconclusive.Objective To assess for a p...
Correlation between gut pathogens and fecal calprotectin levels in young children with acute diarrhea
Background In cases of acute diarrhea, it is difficult to distinguishbetween bact erial and non-bacterial causes . Increased fecalcalprotectin (f-CP) level is a marker of neutrophil migration in theintestinal lumen and i...
Iron profiles of preterm infants at two months of chronological age
Background Preterm infants are vulnerable to iron deficiency (ID) due to lack of maternal iron stores, repeated phlebotomy, and the body’s increased demand for iron during growth. The risk of ID increases at 2 months of...
Third trimester maternal 1,25-dihydroxyvitamin D and neonatal birth weight
AbstractBackground The main cause of neonatal mortality is low birth weight. Active form of vitamin D (1,25-dihydroxyvitamin D) increase the efficiency of calcium and phosphorous absorption in intestinal. Deficiency 1,25...