IMPACT OF PHYSICAL TREATMENTS ON STABILITY AND RADICAL SCAVENGING CAPACITY OF ANTHOCYANIDINS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 1
Abstract
Objective: The aim of the study was to evaluate the chemical stability and antioxidant ability of selected anthocyanidin (ACN) upon various commonly used physical treatments.Methods: Pure compounds of representative ACNs (cyanidin, peonidin) were subjected to microwave, heat, and sonication treatments followed by analyzing the rate of degradation by LC-MS. The changes in the antioxidant ability of ACNs were also assessed by DPPH and ABTS assay.Results: All the tested treatment strategies accelerated the degradation and diminished the antioxidant capacity of pure ACN, more specifically heat exposure cause ~ 90% of degradation and ~3 fold reduction in antioxidant capacity. About 91.34% and 87.73% of cyanidin and peonidin degradation were documented after heat treatment, respectively. Relatively sonication has not accelerated the ACN debasement, but significant level of degradation (p<0.05) was observed.Conclusion: The study results suggested that the maximum concern is required for the selection of the method of the degerming process during the production of precious formulations. This study revealed that microwave and sonication processes are better than dry heat based aseptic methods for pure ACNs based product, especially in pharmaceuticals with respect to the stability and bioactivity of ACN.Â
Authors and Affiliations
Bhagavathi Sundaram Sivamaruthi, Noppawat Pengkumsri, Manee Saelee, Periyanaina Kesika, Sasithorn Sirilun, Sartjin Peerajan, Chaiyavat Chaiyasut
Keywords
Related Articles
- EP ID EP577933
- DOI -
- Views 46
- Downloads 0
Validation of two spectrophotometric methods for fluoxetine quantification
Objective: This paper describes the development and validation of two UV-Visible spectrophotometric analysis methods, using absolute ethanol (method A) and HCl 0.1 M (method B) as solvents, to quantify fluoxetine (FLX) i...
STEREO SELECTIVE SYNTHESIS OF NOVEL LIGNAN INTERMEDIATES AS ANTIMICROBIAL AGENTS
Objectives: The aim of the present study was to synthesize a series of new lignan intermediates as potential antimicrobial agents.Methods: Substituted benzene and aromatic acids or acid chlorides were converted to benzop...
ANTIOXIDANT, ANTI-LIPID PEROXIDATIVE AND ANTIMICROBIAL PROPERTIES OF THE EPIPHYTIC FERN, PYRROSIA HETEROPHYLLA (L.) M. G. PRICE
Objective: The present study was aimed at establishing the antioxidant, free radical scavenging, anti-lipid peroxidative and antimicrobial properties of the plant Pyrrosia heterophylla (L.) M. G. PRICE.Methods: Standard...
CURRENT TREATMENTS FOR TYPE 2 DIABETES, THEIR SIDE EFFECTS AND POSSIBLE COMPLEMENTARY TREATMENTS
Diabetes mellitus is a chronic metabolic disorder in the endocrine system and characterized by a varied and complex pathophysiology. World-wide there is a dramatic increase in the number of patients for type 2 diabetes,...
PHYTOCHEMICAL SCREENING, GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS) ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS AND ANTIBACTERIAL ACTIVITY OF CORIANDRUM SATIVUM (L) SEEDS
Objective: The present study was carried out to evaluate the phytochemical screening, Gas Chromatography–Mass Spectrometry analysis of phyto-constituents and antibacterial activity of Coriandrum sativum (L.) seeds agai...