Impact Of Prolonged Intake Of Sugar-Free Carbonated Soft Drinks On Reproductive Outcomes Of Male Wistar Rats.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
The impacts of prolonged intake of sugar-free carbonated soft drink on reproductive parameters of adult male Wistar rats were studied. Thirty (30) wistar rats weighing between 175g to 225g were used in this study. They were separated into five (5) groups of six (6) rats each. Animals in groups 1, 2, 3, 4, and 5 were fed normal feed and water, and in addition, groups 2, 3, 4 and 5 received 1.4mlkg-1 B.W of popular regular cola drink, 3mlkg-1 B.W of popular regular cola drink, 1.4mlkg-1 B.W of sugar-free cola brand and 3mlkg-1 B.W of sugar-free cola brand respectively. Three experimental animals were sacrificed after 3 and 6 weeks of treatment and reproductive parameters were assayed. Reproductive assessment showed reduction in testosterone levels with administration of both cola drinks though not significant (p ≥ 0.05). Administration of the popular regular cola and sugar free cola drink raised observed sperm morphology and percentage death. However, there was an observed decrease in sperm motility, and count in sugar-free cola. The study suggests that prolonged administration of regular cola and sugar-free cola may be predisposing factors for abnormal disturbance in sperm quality parameter and testosterone level and is a possible indication of fertility problem. Generally, extension of the treatment for a long period may actually predispose the animals to fertility problems.
Authors and Affiliations
Anacletus, F. C, Uzobor, P. U, Nwaichi, E. O
Keywords
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- EP ID EP395425
- DOI 10.9790/3008-1303050711
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