Role of Serum Cholesterol and Statin Usage in Predicting Nosocomial Surgical Site Infections after Gastrointestinal Surgery
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Total serum cholesterol levels and the use of statin medications are associated with incidence of complications after gastrointestinal surgery. low total serum cholesterol may contribute to the development of infections in induviduals undergoing surgery. It has been postulated that total cholesterol, VLDL, LDL, HDL can protect against endotoxin mediated sepsis.Cholesterol rich lipoproteins , they have the capacity to bind and detoxify bacterial lipopolysaccharide. Circulating cholesterol-rich lipoproteins and triglyceride-rich lipoproteins have the capacity to bind and detoxify bacterial lipopolysaccharide (LPS) . HDL has been shown to compete with lipopolysaccharide binding protein (LBP) for binding to lipopolysaccharide (LPS). The lipopolysaccharide-lipopolyscacharide binding protein (LPS-LBP) complex attaches to the cd-14 receptor on cells, which, in turn, stimulates TNF production, thus producing inflammation and infection. Secondly,cholesterol also affects gluconeogenesis and immune function.The transport forms namely the lipoproteins also serve as vehicles for anti-oxidants,fat soluble vitamins,drugs etc…Thus,high cholesterol might be protective ,possibly through a beneficial effect on the immune system.Based on these theories the nature of association between serum cholesterol and surgical site infections is to be evaluated under this study i.e is serum cholesterol a risk factor for the development of surgical site infections.
Authors and Affiliations
Dr. R Manivannan Ms, Dr. Sr. Prasad
Keywords
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- EP ID EP440459
- DOI 10.9790/0853-1801110509.
- Views 55
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