Impact of proteolysis processes on development and progressing of cardiac insufficiency of is chemic genesis depending on revascularisation
Journal Title: Медичні перспективи - Year 2013, Vol 18, Issue 1
Abstract
Investigation and comparative assessment of the activity of matrix metalloproteinases MMP-9 and MMP-2 in 187 patients with chronic ischemic heart disease and all forms of acute coronary syndrome mean age 62 ± 1,5 years in applying the standard basic therapy, thrombolytic and antithrombin therapy was carried out. It was established, that in patients with acute coronary syndrome and chronic ischemic heart disease; diverse changes in activity of the processes of proteolysis are observed, the presence of heart failure leads to a comparative increase in the activity of MMP-2 and MMP-9 in patients with acute coronary syndrome, but a greater effect on these processes causes the time of the beginning of treatment and receiving throm¬bolytic therapy; significant increasing activity of both matrix metal-pro¬teinases is associated with the long process of formation and progression of heart failure, with the development of severe chronic heart failure, a gradual decrease in activity of matrix metal-proteinases.
Authors and Affiliations
A. Skoromna
Keywords
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- EP ID EP115451
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