Impact of Serum Sodium with Severity of Complications of Cirrhosis: A Prospective Study in Tertiary Medical Center of Rajasthan
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 5
Abstract
Background/Aim: Hyponatremia is an independent predictor of mortality in patients of cirrhosis, but the prevalence and the impact of the prognostic value of serum sodium levels on complications of cirrhosis are unclear. This study was done with the aim to identify prevalence of hyponatremia and to analyze the relationship between serum sodium levels and severity of ascites and complications of cirrhosis. Patients and Methods: In this prospective study 191 patients with liver cirrhosis were analyzed for demographic, clinical and biochemical parameters. Results: The prevalence of low serum sodium concentration as defined by a serum sodium concentration ≤135meq/l, 130meq/l was 12% and 40% respectively. Low serum sodium ≤135meq/l was associated with severe ascites as assessed by frequent need for paracentesis and impaired renal function, compared with normal serum sodium levels. Low serum sodium levels have also shown association with more frequent episodes of hepatic encephalopathy, spontaneous bacterial peritonitis, and hepato renal syndrome, but not gastrointestinal bleeding. These complications were more frequently seen in patients with serum sodium less than 130meq/l but the frequency also increased with mild reduction in serum sodium (131-135meq/l). Conclusion: Hyponatremia in cirrhotics is associated with severe ascites with repeated paracentesis and increase frequency of hepatic encephalopathy, spontaneous bacterial peritonitis and hepato-renal syndrome.
Authors and Affiliations
Gaurav Kumar Gupta, Ram Pratap Singh, Dhawal Vyas, Sandeep Nijhawan
Keywords
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- EP ID EP547477
- DOI 10.21276/ijmrp.2017.3.5.012
- Views 49
- Downloads 0
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