Implication of age and gender on cardio toxicity in patients treated with two schedules of 5FU/LV
Journal Title: Pakistan Journal of Pharmacology - Year 2012, Vol 29, Issue 2
Abstract
Cardio toxicity induced by chemotherapeutic agents can interfere with the cumulative therapeutic benefit and debilitate the elderly with a comorbid burden. The cardio toxic potential of 5-FU based chemotherapy is known, however the specific risk in elderly patients is yet to be defined. The gender specific risk of toxicity induced by chemotherapeutic agents has been a wide area of debate. This prospective clinical study is designed to assess the cardio toxicity in patients treated with two schedules of 5-FU with high and low dose leucovorin. The cardiac markers, blood pressure, glucose levels and pulse rate of the patients were monitored to suggest any toxicity imparted by chemotherapy. The comparative assessment was made according to gender and age group of the patients. Significant risk of drug induced hypertension was seen in few patients of age below 60 years. The risk of cardio toxicity was not significant in either gender; however substantial risk of cardio toxicity in few elderly patients exacerbated as anginal pain was reported.
Authors and Affiliations
Nusrat Bano, Rahila Najam, Ahmed Mateen, Faaiza Qazi
Keywords
Related Articles
- EP ID EP156518
- DOI -
- Views 87
- Downloads 0
To study the efficacy and safety of combination treatment using allopurinol and fenofibrate in patients with hyperuricemia
Allopurinol is the most frequently used antihyperuricemic drug. Fenofibrate, a derivative of fibric acid, is commonly used in the treatment of hyperlipidemia. Fenofibrate treatment has been shown to decrease serum urate...
Comparative study of succinylcholine and precurarization with rocuronium on muscular effects in patients undergoing surgery under general anaesthesia
Succinylcholine remains the drug of choice in conditions where rapid paralysis and airway control are priorities. However it is associated with muscular side effects that have an overall incidence ranging from five to 83...
Renal clearance and urinary excretion of ciprofloxacin in lohi sheep
This study was undertaken with objective to investigate the renal clearance and urinary excretion of ciprofloxacin in eight sheep of Lohi breed. Ciprofloxacin was administered at the rate of 5 mg/kg body weight intramusc...
Evaluation of anti A60 IGM for the diagnosis of tuberculosis with elisa method
Evaluation of Anti Tuberculous IgM antibodies for rapid diagnosis of both pulmonary and extra-pulmonary tuberculosis. ELISA assay based on mycobacterial antigen A-60 (Anda Biologicals, France) was used on the sera obtain...
Incretin mimetics: new age drugs for type 2 diabetes mellitus
Type 2 diabetes mellitus is a fast growing global epidemic and its prevalence has increased in the 21st century. The rise in blood glucose levels is associated with complex pathogenesis which includes a significant reduc...