IMPROVE ORAL BIOAVAILABILITY OF ACECLOFENAC USING SOLID DISPERSIONS BY DROPPING METHOD
Journal Title: International Journal of Pharmaceutical, Biological and Chemical Sciences (IJPBCS) - Year 2012, Vol 1, Issue 2
Abstract
The objective of the present investigation was to study the effect of polyethylene glycol 8000 (PEG 8000) on in vitro dissolution of Aceclofenac from solid dispersions. Initial studies were carried out using physical mixtures of the drug and carrier. Solid dispersions were prepared by the dropping method. Aceclofenac was formulated as physical mixtures and solid dispersions (dropping method) using 1:2, 1:4, 1:6 and 1:8 ratios of drug and carrier (PEG 8000). Saturation solubility study for pure drug, physical mixtures and solid dispersions were carried out in water and pH 6.8 phosphate buffer solutions (PBS). The In vitro dissolution studies were carried in pH 6.8, higher in vitro dissolution of solid dispersions was recorded compared to their corresponding physical mixtures and the pure drug. The prepared solid dispersions showed marked increase in the saturation solubility and dissolution rate of Aceclofenac than that of pure drug. PEG 8000 in 1: 8 drug to carrier ratio exhibited the highest drug release (98.83%) formulated as solid dispersions using dropping method. The FT-IR shows the complexation and there were no interactions. Finally solid dispersion of Aceclofenac: PEG 8000 prepared as 1:8 ratio by dropping method showed excellent physicochemical characteristics and was found to be described by dissolution release kinetics and was selected as the best formulation.
Authors and Affiliations
Venkatewara Reddy. B*1, M. Vijaya Gopal1, Jyosna. D1 , K. V. Ramana Murthy2
Keywords
Related Articles
- EP ID EP114469
- DOI -
- Views 113
- Downloads 0
RP-HPLC VALIDATION OF RELATED SUBSTANCES OF NEBIVOLOL IN BULK & 2.5/5/10/20 MG TABLETS
A gradient reverse phase HPLC method was developed for the determination of related substances in Nebivolol in bulk and their tablets. The known related substances are Desfuoroimpurity[1-(chroman-2-yl)-2-(2-(6fluorochrom...
DEVELOPMENT AND VALIDATION OF ANALYTICAL TECHNIQUE FOR NON STEROIDAL ANTI INFLAMMATORY DRUGS (NSAIDs) BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)
Drug analysis plays an important role in the development of drugs, their manufacture and therapeutic use. Pharmaceutical industries rely upon quantitative chemical analysis to ensure that the raw material used and final...
ESTIMATION OF RELATED SUBSTANCES OF FEBUXOSTAT IN BULK & 40/80/120mg TABLETS BY RP-HPLC
A simple reverse phase liquid chromatographic method was developed for the determination of related substances in Febuxostat in bulk and Tablets. The related substances amide impurity, methyl ester impurity and ethyl est...
QUALITY EVALUATION OF MARKETED FORMULATION OF MOUTH DISSOLVING VOGLIBOSE TABLETS
The main objective of this study was to compare the five brands of mouth dissolving tablets containing voglibose, an antidiabetic. Novel MDT technique provides the patient compliance and also meets the pharmaceutical...
A REVIEW OF NOVEL APPROACH IN BILAYER TABLET TECHNOLOGY
Over the past 30 years as the expense and complications involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention ha...