IMPROVED DISSOLUTION CHARACTERISTICS AND SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG BY NOVEL METHOD USING NATURAL GUM AND WATER SOLUBLE POLYMER
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2018, Vol 8, Issue 2
Abstract
The main objective of the present study is too prepared, characterized and evaluate and surfactant used as a carrier in solid dispersions for enhancing the dissolution rate of simvastatin. The feasibility of formulating solid dispersions of pure drug with gum and surfactant combination that enhanced dissolution rate was also investigated. Solid dispersions of simvastatin in gum: surfactant different polymer ratios were prepared by kneading method and evaluated for dissolution rate and efficiency. All the solid dispersions prepared gave rapid and higher dissolution of simvastatin when compared with pure drug. The DE60 was also increased from many folds in the case of pure drug and solid dispersions. Experimental design was applied systematically and determine the influence of the individual and combined effect on independent variables (X1) ratio and (X2) concentration of surfactants on the dependent variables percent dissolution efficiency at 60 min (%DE 60) and yield percent and optimized formulation selected and characterised by its UV, Differential scanning caloriemetery, Scanning electron microscopy and X- Diffraction studies and formulated into capsule dosage form. In conclusion, the result of this work to suggest that solid dispersion is a useful technique for enhancing the solubility and dissolution study of water insoluble drug. Keywords: Solubility enhancement, Poorly water soluble drug, Simvastatin, Solid dispersions
Antibiotic evaluation of odontogenic microbiological spectrum of orofacial infection
The present study aimed towards the development of active delivery system for management of hypertension. The Orodispersible tablets (ODTs) containing Telmisartan was developed in order to accomplish enhanced solubility...
FORMULATION AND EVALUATION OF TROPICAMIDE IN-SITU GELS LOADED SOLID LIPID NANOPARTICLES FOR OCULAR DRUG DELIVERY
The aim of present work Formulation and Evaluation of Tropicamide In-situ Gels loaded Solid Lipid Nanoparticles for Ocular Drug Delivery. The surface morphological of SLN was carried out by TEM. The Tropicamide loaded so...
Formulation and development of fast dissolving oral film of a poorly soluble drug, frusemide with improved drug loading using mixed solvency concept and its evaluation
The aim of the present research work is to explore the application of mixed solvency concept to formulate and develop a fast dissolving oral film of furosemide with improved drug loading. In the present study, poorly sol...
LAXATIVE ACTIVITY OF HYDROALCOHOLIC LEAVES EXTRACT OF PUTRANJIVA ROXBURGHII.
Background: This study was aimed to assess the possible laxative effect of roxburghii hydroalcoholic leaves extract of Putranjiva in albino’s Wistar rats. Method: Rats were divided in 5 groups of 6 animals each, I gro...
DIALLYLDISULFIDE CONTAINING POLYMERIC NANOPARTICLES FOR SITE-SPECIFIC DELIVERY IN COLON CANCER
Effective delivery of drugs to colon is a challenge, as the drug needs to be protected from gastrointestinal environment and should be released intact in colon. Present study is aimed to develop a site-specific nanopart...