Improved Enantioselective Enzymatic Synthesis of (S) - Pregabalin
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 1, Issue 3
Abstract
Pregabalin is available in the market under the brand name of Lyrica among others. It is a drug of choice for the treatment of epilepsy, fibromyalgia, sweeping anxiety disorder and neuropathic pain. It effectively relieves neuropathic pain (pain from damaged nerves) that occurs in your arms, hands, fingers, legs, feet, or toes if you are diabetic or in the area of your rash if you once were affected with shingles (a rash that occurs due to infection with herpes zoster and is also painful) [1]. Pregabalin also finds use in the treatment of fibromyalgia (which is a long-lasting condition causing pain, fatigue, muscle stiffness, tenderness of muscles and difficulty in falling asleep or staying asleep [1]. Pregabalin is used in combination therapy with certain other medications for the treatment of various types of seizures in people who have epilepsy. Pregabalin comes under the class of medications that are known as anticonvulsants [2]. In 1990, Pregabalin was synthesized as an anticonvulsant and was invented by medicinal chemist Richard Bruce Silverman at Northwestern University of Chicago, Illinois [3]. The drug received approval in the European Union in the year of 2004. The US also received FDA approval for its use in treatment of epilepsy, post-therapeutic neuralgia and diabetic neuropathic pain in the December of 2004. It was launched in the US market as Lyrica in the fall of 2005 [4]. Pregabalin also received approval in the European Union and Russia (not in US) for treating generalized anxiety disorder [5].
Authors and Affiliations
Madhuresh Sethi
Keywords
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- EP ID EP598694
- DOI 10.32474/AOICS.2018.01.000115
- Views 84
- Downloads 0
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