IMPROVED GLUCOSE TOLERANCE WITH A POLYHERBAL FORMULATION OF COLOCASIA ESCULENTA TUBERS AND ALLIUM SATIVUM CLOVES
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 9
Abstract
Background: Colocasia esculenta and Allium sativum are cultivated in Bangladesh, respectively, for consumption of tubers as vegetable and use of cloves as spice. Both plant parts have previously been reported to have antihyperglycemic properties. It was therefore of interest to determine the antihyperglycemic potential of a polyherbal formulation containing the tubers of the first and cloves of the second plant. Methods: Oral glucose tolerance test (OGTT) was done to evaluate antihyperglycemic potential. Results: In oral glucose tolerance tests, methanol extract of tubers of Colocasia esculenta (MECE), administered at a dose of 400 mg per kg body weight reduced blood glucose by 31.5%. Methanol extract of cloves of Allium sativum (MEAS), administered at the same dose reduced blood glucose by 31.8%. Administration of a combination of MECE and MEAS (1:1, w/w), tentatively termed MECEAS, significantly and dose-dependently reduced blood glucose levels in glucose-loaded mice by 32.2, 36.6, 40.1, and 45.5%, respectively, at doses of 50, 100, 200 and 400 mg each per kg body weight in mice. Thus even at the lowest dose, MECEAS exhibited better antihyperglycemic properties than MECE or MEAS at their highest doses, when administered singly. By comparison, a standard antihyperglycemic drug, glibenclamide, reduced blood glucose levels by 46.9% at a dose of 10 mg per kg. Conclusion: MECEAS can be used as a blood glucose lowering agent in diabetic patients.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
Related Articles
- EP ID EP627014
- DOI -
- Views 111
- Downloads 0
THE CONCEPT OF TAILA BINDU PARIKSHA – AS A DIAGNOSTIC AND PROGNOSTIC TOOL
Taila Bindu pariksha is an ancient technique described in medieval Ayurvedic texts by which prognosis and diagnosis can be predicted. This study aims at using this ancient wisdom to diagnose the medical conditions and to...
THE INFLUENCE OF GREEN LOW LEVEL LASER (532 NM) IRRADIATION ON WOUND HEALING
Background: Many workers indicating the ability of low level laser in accelerating wound healing. Two different doses (5.7, and 11.4 J/cm2) from a green laser light (532 nm) were employed on a superficial wound on rats d...
ANTIMICROBIAL ACTIVITY OF PSIDIUM GUAJAVA LEAVES EXTRACT AGAINST STAPHYLOCOCCUS AUREUS USING PURE EXTRACTS
The key role in the treatment of the patients, is to use the pharmacologic therapy of the extract which can b used as an alternative, which is beneficial in terms of cost effectiveness, availability and potency. particul...
INDICATIONS FOR CESAREAN SECTION IN A SAMPLE OF WOMEN IN BAGHDAD CITY
Background: cesarean section has traditionally performed when a vaginal would put the mother or baby's life at risk. Cesarean section rate has risen worldwide in the last decades, in 2009 it was 34% in the Unit State of...
AN UPDATE ON DIGITAL DENTISTRY
To date, there has been various softwares used in the field of dentistry as a whole, be it in case history, imaging and in clinical practice management. This article classifies the different types of dental softwares and...