Improvement of endothelial function and external respiration in patients with comorbidity of hypertension and stage III chronic obstructive pulmonary disease, using nitric oxide donor — L-arginine
Journal Title: Туберкульоз, легеневі хвороби, ВІЛ-інфекція - Year 2018, Vol 0, Issue 4
Abstract
Objective — to improve the efficacy of pharmacotherapy for patients with comorbidity of arterial hypertension (AH) and stage III chronic obstructive pulmonary disease (COPD) (group C), using an exogenous nitric oxide donor — L-arginine by correction of endothelial function as well as to improve pulmonary ventilation and quality of life in general. Materials and methods. This study involved 102 patients with stage 2 arterial hypertension (AH) (2-nd and 3-rd degree) including 82 patients with AH and concomitant COPD III stage, group C, and 20 patients with essential hypertension of the identical stage and degree at the age of (65.5 ± 4.12). According to the treatment 82 patients with AH and COPD were divided into two groups, homogeneous by age, sex, duration of AH and COPD. Group I — the control group (CG) — included 40 patients receiving basic therapy only, group II — the main group (MG) — included 42 patients, who received L-arginine hydrochloride in addition to basic therapy. Patients with AH were divided similar. Results and discussion. It has been observed that chronic obstructive disease burdened the course of hypertension by cardiorespiratory system rates deterioration. According to the spirogram in patients with comorbidity the forced expiratory volume in one second was (38.28 ± 1.33) % compared to patients with АH (67 ± 2.84) indicating a reverse negative correlation with the indicator of endothelin — 1 (ET 1) level in plasma(r = –0.45, р < 0.05). Thus, in patients with AH and concomitant COPD, the bronchial patency was significantly impaired due to increasing of endothelin — 1 (ET 1) level — marker of vasoconstriction and endothelial dysfunction (ED). 3 months after basic therapy with L-arginine, a number of positive effects in combination therapy was established: the decrease of endothelin — 1 (ET 1) level in plasma due to treatment, contributed to the improvement of endothelial function, increase in ventilation and gas exchange, as indicated by increased Tiffeneau index, while in the CG — significant changes in ventilation rates have not been noted, which is associated with the absence of bronchial obstruction in this patient cohort, the level of ET 1 decreased (p < 0.05) and significantly improved the endothelial function. Conclusions. The addition of L-arginine to the combined therapy of patients with hypertension accompanied by COPD, resulted in the potentiation of antihypertensive therapy, improvement of bronchial patency and endothelial function as well as to the improvement of quality of life in general.
Authors and Affiliations
L. A. Dron, I. H. Kupnovytska
Keywords
Related Articles
- EP ID EP462317
- DOI 10.30978/TB2018-4-66
- Views 76
- Downloads 0
Histologically confirmed pulmonary aspergillosis in patients with light and moderate immunosuppression
In the article a modern forms of pulmonary aspergillus infection are describes in detail, which are widely spread fungi in nature, and which can be saprophytes relatively to the human body or cause severe, diverse in cli...
WHO consolidated guidelines on drug-resistant tuberculosis treatment. Part 1
_
Experience of selection, indication and identication of non-tuberculous mycobacteria, got during I National research on study of distribution of drugresistant of tuberculosis in Ukraine
Objective — a study of presence of non-tuberculosis mycobacteriumin a circulatory mycobacterial population among patients by a white plague in Ukraine, finding out of etiologic role of non-tuberculosis mycobacterium, the...
First results of the introduction of bedaguiline for patients with multidrug resistens tuberculosis in Ukraine: recommendations for practical doctor resume
Objective — to implement approaches for the proper use of new and reprogrammed drugs for the treatment of drug-resistant tuberculosis. Materials and methods. Such an implementation took place within the pilot project Ch...
Improvement of endothelial function and external respiration in patients with comorbidity of hypertension and stage III chronic obstructive pulmonary disease, using nitric oxide donor — L-arginine
Objective — to improve the efficacy of pharmacotherapy for patients with comorbidity of arterial hypertension (AH) and stage III chronic obstructive pulmonary disease (COPD) (group C), using an exogenous nitric oxide don...