IMUNOLOŠKI ODGOVOR KOD INFEKCIJA IZAZVANIH HELMINTIMA
Journal Title: Acta Facultatis Medicae Naissensis - Year 2013, Vol 30, Issue 0
Abstract
Pored urođene otpornosti, u borbi protiv parazita, organizam domaćina raspolaže i specifičnim humoralnim i celularnim mehanizmima zaštite. Celularna imunska reaktivnost u toku helmintoza uspostavlja se preko Th2 imunskog odgovora. Imajući u vidu činjenicu da cilj parazita nije da ubije svog domaćina, većina parazita je visoko adaptirana na život unutar domaćina i uspešno izbegava ili ograničava njegove odbrambene sposobnosti. Helminti, paraziti čoveka, produkuju određene supstance koje deluju kao supresori limfocita i inaktivatori makrofaga i sposobni su da izvrše destrukciju produkovanih antitela. Takođe, helminti mogu maskiranjem, sekvencioniranjem i gubitkom eksponiranih antigena kutikule da izbegnu mehanizme odbrane nosioca. Najnovija istraživanja na polju imunologije otkrivaju značaj CD40 kostimulirajućeg proteina antigen prezentujućih ćelija u okviru imunološkog odgovora u toku parazitske infekcije. Pored zaštitne uloge, imunološki odgovor u toku parazitske infekcije značajno utiče i na patogenezu helmintoza.
Authors and Affiliations
Dragan Zdravković, Jovana Kostić, Aleksandar Kostić, Milena Potić Floranović, Ana Ristić Petrović, Aleksandra Ignjatović, Nataša Miladinović Tasić, Suzana Otašević
Keywords
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- EP ID EP104798
- DOI 10.2478/afmnai-2013-0002
- Views 110
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