In An Incisional Model of Wound Healing, Genistein Aglycone Enhances Skin Recovery: A Comparison with Raloxifene and Estradiol in Ovariectomized Rats Is Presented
Journal Title: Journal of Dermatology Research - Year 2024, Vol 5, Issue 1
Abstract
Context and goal: Poor wound healing is commonly associated with estrogen depletion during menopause. Experiments on anti-aging cosmetic formulations using genistein have yielded intriguing findings about skin health. Here, we examined the effects of systemically administered the genistein aglycones in an incisional wound healing model in comparison to systemically administered estradiol and raloxifene. Method of experimentation: Rats were randomly divided into groups of 12 animals each six months after Ovariectomies (OVX) and given daily treatments of raloxifene hydrochloride (0.05 and 0.5 mg·kg-1s.c.), genistein aglycone (1 and 10 mg·kg-1s.c.) or 17-a-ethinyl estradiol (0.003 and 0.03 mg·kg-1s.c.) for a period of 12 weeks. Rats with OVX and sham OVX were not treated and served as controls. Then, an incisional wound healing technique was carried out 14 or 7 days before to the experiment’s conclusion and skin specimens were gathered to assess molecular, histological and functional measurements. Important Results: Compared to samples from sham OVX animals, samples from OVX rats seven and fourteen days after wounding shown a decrease in transforming growthfactor-b1, tissue transglutaminase 2 and vascular endothelial growth factor. Genistein, raloxifene and estradiol all considerably altered this decline, but the lowest dose of genistein had a stronger impact than the other two therapies. Furthermore, the best genistein dosage for enhancing wound tensile strength and skin healing was the lowest one. Inferences and conclusions: One potential alternative treatment for the control of skin wound healing is genistein aglycone.
Authors and Affiliations
Hari Prasad Sonwani1*
Keywords
Related Articles
- EP ID EP727319
- DOI https://doi.org/10.46889/JDR.2024.5102
- Views 42
- Downloads 0
The Role of Oral Cyclosporine in the Management of Steven Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Multicentric Observational Study
Background: SJS and TEN are severe life threatening muco-cutaneous reactions characterised by extensive epidermal sloughing with mucosal erosions. Objective: The main objective of this study was to observe the effectiv...
Vulvar Lesion Mimicking Vitiligo Revealing a Squamous Cell Carcinoma
Melanocytes respond to trauma or cutaneous inflammation by producing varying amounts of melanin, which manifests as either hyperpigmentation or hypopigmentation. Post inflammatory Hypopigmentation (PIH) is an acquired pa...
Analysis of Quality of Life in Relation with Physical and Psychological Morbidity in Patients of Psoriasis
Objective: To study the effect on quality of life and to study the prevalence of metabolic syndrome in psoriatic cases compared to healthy controls. Methods: After approval from ethics committee, hospital based cross...
Endothelial TLR4 Activation by Endogenous Ligands Contributes to Small Blood Vessels Formation in Angiolipoma
Angiolipomas are benign subcutaneous nodules characterized by the presence of mature adipocytes intermingled with cluster of small blood vessels, often displaying intraluminal fibrin microthrombi. It is known that fibrin...
The Weight of Traditional Therapy in The Management of Chronic Skin Diseases in Donka National Hospital
Chronic skin diseases affect patients’ physical, psychological and social well-being. They lead patients to seek care in conventional and traditional medicine. The aim of this study was to determine the contributions of...