In silico analysis and identification of novel inhibitor for new H1N1 swine influenza virus
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2014, Vol 4, Issue 0
Abstract
Objective: To identify alternative drug for the treatment of pandemic disease caused by influenza virus. Methods: The structure based drug design approach was employed. New sequence was employed to build the N1 simulation structure by homology modeling which was further checked for high reliability by verify score and Ramachandran plot. Evaluation of drug likeness and absorption, distribution, metabolism, excretion, toxicity showed that the ligands satisfy all the properties to be used as a drug. Docking studies were performed using LeadIT and docking scores indicated good binding energy values towards N1. Results: Four candidates were screened and suggested as potent target candidates from the docking studies. The screened compounds from Stemonaceae family illustrated better activity compared to the drugs which are already present in the market. Conclusions: The results may help to find the alternative drug to solve the drug-resistant problem and stimulate designing more effective drugs against 2009-H1N1 influenza pandemic, yet pharmacological studies have to confirm it.
Effect of embelin on lithium-induced nephrogenic diabetes insipidus in albino rats
Objective: To evaluate the nephroprotective and anti-polyuric role of embelin on lithium induced nephrogenic diabetes insipidus (NDI) in albino rats. Methods: NDI induced by lithium chloride (4 meq/kg/day, i.p. for 6 day...
Cardioprotective effect of Nelumbo nucifera on mitochondrial lipid peroxides, enzymes and electrolytes against isoproterenol induced cardiotoxicity in Wistar rats.
Objective: To explore the protective effect of Nelumbo nucifera leaf extract (NNE) on the levels of mitochondrial lipid peroxides, activities of TCA cycle and respiratory chain enzymes and electrolytes in isoproterenol (...
A relapse case of HIV-PKDL co-infection associated with diabetes and its microvascular complications
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A study of the knowledge on HIV in regards to routes of transmission and sexual practices in men between the ages of 20 to 50 in Tehran
Objective: To study the knowledge of 20-50 years old men regarding HIV transmission routes and their sexual practices in 2012. Methods: A cross sectional study on 20-50 years old men visiting barber shops in Tehran, Iran...
First report of some adult mosquitoes captured by CDC gravid traps from North-Eastern Qatar
Objective: To report six species of female mosquitoes caught in CDC gravid traps for the first time in Qatar. Methods: Five traps were installed in Al-Khor community, north-eastern Qatar during the outbreak season betwee...