In-silico analysis of active compounds has potential inhibitors against diabetic
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Plants are naturally produced important sources of medicines. Today, a large number of drugs in use derived from plants. A Decalepis hamiltonii (Asclepiadaceae) to treat the various diseases of to human such as diabetic and cancer. GC MS Analysis was carried out to identify the compounds of the selected drug and In silico studies carried out to assess the antidiabetic potential. In silico docking exercise of different herbal based ligands with anti-diabetic properties, revealed that PBRƴ got docked onto diabetic protein with the lowest calculated interaction energy. The oleic acid (-14.29 kJ mol−1) was docked into active site of ERRα receptor. The green dotted line denoted the hydrogen bonds. The interactions of amino acid residues involved in molecular interactions with oleic acid. In this study, it is confirmed that the Decalepis hamiltonii has significant anti-diabetic activity.
Authors and Affiliations
Palanisamy Prakash, Rengarajan Manivasagaperumal2*
Keywords
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- EP ID EP390341
- DOI 10.9790/3008-1204074449
- Views 68
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