In silico structure based molecular expression and modeling of PTEN gene for proteus syndrome
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 3
Abstract
Proteus syndrome is a very complex and rare to find in world. It consists asymmetric and disproportionate overgrowth in bones and skins. There are very few cases that have been come in light all over the world such as 1 over 1 million. The drug designing is the inventive process of finding new medications based on the knowledge of a biological target. It also involves the design of small molecules that are complementary in shape and charge to the bimolecular target with which they interact and therefore will bind to it. Proteus syndrome is caused by AKT1 and PTEN genes. The PTEN gene is taken for the modeling and research. It consists 403 amino acids and it acts as a tumor suppressor. Proteus syndrome is not a disease but a disorder. It is related to the PI3K-AKT Signaling Pathway which eventually led to the clinical approaches as their effect. So that, the structure based molecular expression and modeling can be taken to a direction and lead to the mainly drug designing for the welfare of the suffering persons of this syndrome.
Authors and Affiliations
Ayushi Arya
Keywords
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