IN VITRO α-AMYLASE AND α-GLUCOSIDASE INHIBITORY EFFECTS OF ETHANOLIC EXTRACT OF EVOLVULUS ALSINOIDES (L.)
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Diabetes mellitus is a disorder in carbohydrate metabolism of endocrine system due to an absolute or relative deficiency of insulin secretion, action, or both. There has been an enormous interest in the development of alternative medicines for type 2 diabetes, specifically screening for phytochemicals with the ability to delay or prevent glucose absorption. Pancreatic α-amylase and glucosidase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control of starch breakdown. The goal of the present study was to provide in vitro evidence for potential inhibition of α-glucosidase and α-amylase enzymes by using the ethanolic extract of Evolvulus alsinoides. The results showed a significant (more than 70%) reduction in α –amylase activity as well as 50% reduction in α-glucosidase activity. The present study suggests that the extract of Evolvulus alsinoides effectively act as alpha amylase and alpha glucosidase inhibitor leading to a reduction in starch hydrolysis and hence eventually to lowered glucose levels.
Authors and Affiliations
Gomathi Duraisamy , Kalaiselvi Manokaran , Uma Chandrasekar
Keywords
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