Abstract

Objective: Anthelmintic resistance creates a major hitch over the decades throughout the world. As per WHO only synthetic drugs are frequently used in the treatment of helminth infestations in human beings but these synthetic drugs are out of reach of millions of people and have a lot of side effects. In view of this, an attempt has been made to study the anthelmintic activity of herbal drug. Methods: All the prototypes and the standard drug solution were freshly prepared before commencement of the experiments. All the earthworms were washed in normal saline solution before they were released into 10 ml of respective formulation as follows, vehicle (2% v/v Tween 80 in normal saline), and Piperazine Citrate (10 mg/ml) and prototypes (10, 20 and 50mg/ml). Results: All the investigational extract acquired the anthelmintic activity at minimal dose of 10 mg/ml. its significant activity (P<0.05) at 10 mg/ml for time taken to paralysis and death when compared to the standard drugs Piperzine citrate used at 10 mg/ml respectively. Conclusions: Herbal drugs and synthetic drugs have equally effective in helminth infestations but methanolic extract has the maximum anthelmintic activity potential than other root extract of Coleus aromaticus.

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