IN VITRO ANTIBACTERIAL ACTIVITY OF PIPER BETEL LEAVES EXTRACT AGAINST STAPHYLOCOCCUS AUREUS AND CANDIDA ALBICANS
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 12
Abstract
Endodontic irrigating solution used in root canal treatment in dental specialty is to eliminate root canal pathogens in necrotic pulp tissues. A microorganism like Staphylococcus aureus, Candida albicans, Enterococcus faecalis were commonly seen pathogens in necrotic pulp tissues. Commonly used root canal irrigating solutions to kill bacteria’s in the dental root canal are hydrogen peroxide (H2O2), chlorhexidine (CHX) and sodium hypochlorite (NaOCl). These root canal irrigating solutions has detrimental effects on the tissues underlying tooth (periradicular tissues) and affects post-operative healing. NaOCl has tissue toxicity and inhibits phagocytosis. Chlorhexidine inhibits protein synthesis in periodontal ligament cells. CHX and NaOCl exhibit an inflammatory effect in mitochondrial activity in human periodontal cells. Natural products are in great demand for their extensive biological properties and their bioactive molecules. Nontoxic Piper betel leaves extract obtained by methanolic extraction method of 500 mg/ml was tested against Staphylococcus aureus and Candida albicans which are commonly associated with root canal treatment and in failure cases using well agar diffusion method. The result shows piper betel leaves extract has antibacterial activity against these organisms.
Authors and Affiliations
G. Vinodh et al.
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