In vitro Anticancer Activity of Selected Medicinal Plants from Oman
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 15, Issue 5
Abstract
This paper reports in vitro anticancer activity of hexane, chloroform, ethyl acetate, butanol and water extracts obtained from twelve (12) medicinal plants including Aloe dhufarensis, Calotropis procera, Juniperus servaschanica, Lawsonia inermis, Maytenus dhofarensis, Moringa peregrina, Polygala senensis, Punica granatum, Rhazya stricta, Solanum incanum, Teucrium mascatense. and Zataria multiflora collected from Oman. Crude ethanol extracts prepared by maceration of plant materials in ethanol were Kupchan partitioned to give hexane, chloroform, ethyl acetate, butanol and aqueous fractions. Cytotoxicities of the prepared fractions were measured by Alamar blue assay against ovarian cancer cell line (MCAS) and breast cancer cell line (MDA MB231). Thirteen extracts from five plants C. procera, J. servaschanica, M. dhofarensis, S. incanum and T. mascatense were found active against MCAS; hexane extract from J. servaschanica was the most active followed by chloroform extract from leaves of S. incanum (IC50 = 8.50 and 10.90 µg/ml, respectively). Furthermore, nine extracts from these plants except C. procera inhibited the growth of MDA MB321; hexane extract from J. servaschanica was again the most active followed by butanol extract of S. incanum. (IC50 = 11.4 and 19.44 µg/ml, respectively). Ethnobotanical and ethnopharmacological information on flora growing in this intemperate, hot climate region could provide new chemical entities for development of new and more potent cancer chemotherapeutics.
Authors and Affiliations
Sadri Abdullah Said, Yahya Tamimi, Md. Sohail Akhtar, Afaf Mohd Weli, Suleiman Said Al-Khanjari, Qassim Ahmed Al-Riyami
Keywords
Related Articles
- EP ID EP312916
- DOI 10.9734/BJPR/2017/32459
- Views 93
- Downloads 0
Preparation of Poly(3-hydroxybutyrate) Micro- and Nanoparticles as Hydrophobic Drugs Carrier Using Self-emulsifying Nanoemulsion Method
Aims: To correlate the different sizes and morphologies of polymeric particles prepared through the oil-in-water micro- and nanoemulsions. Study Design: Poly(3-hydroxybutyrate) (PHB) micro- and nanoparticles were prepare...
Investigating the In-vivo Antiplasmodial Properties of Aqueous Extract of Moringa oleifera Lam (Moringaceae) Leaves
Aim: The study investigated Moringa oleifera Lam (Moringaceae), for its in-vivo antiplasmodial properties, using a murine model involving Plasmodium berghei. Study Design: Experimental. Places of Study and Duration: Dep...
Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties
Aims: The present study was aimed to isolate active anti proliferative compound/s from the hexane extract of leaves of the mangrove plant Scyphiphora hydrophyllacea C.F.Gaertn. and evaluate their cytotoxic properties. Pl...
Aqueous Extract of Enantia chlorantha (Annonaceae) Prevents the Delay in Chronic Gastric Ulcer Healing Caused by Indomethacin in Rats
Aims: To investigate the ability of Enantia chlorantha aqueous extract to heal acetic acid-induced chronic gastric ulcers and to prevent the delay in chronic ulcer healing induced by indomethacin. Study Design: Random a...
In vitro Cytotoxicity of Scopoletin Derived from Eupatorium laevigatum Lam.
Aims: Eupatorium laevigatum Lam. is commonly used as anti-inflammatory, antiseptic, anti-rheumatic, and in the treatment of colds and ulcers. The present study aimed to characterize the active fractions of the aerial par...