In vitro antifungal activity and metabolites of the essential oil of Minthostachys mollis (muña) leaves.
Journal Title: Revista Peruana de Medicina Experimental y Salud Publica - Year 2008, Vol 25, Issue 3
Abstract
[i][b]Objectives. [/b][/i]Demonstrate the antifungal activity in vitro and elucidation of some metabolites of the essential oil of [i]Minthostachys mollis [/i](muña) leaves from the Huacrapuquio district (2700 m), Junín (Central Peruvian Andes). [b][i]Material and methods.[/i][/b] The essential oil was obtained by the distillation method by drag of water vapor. This was performed to physical-chemical analysis and identification of the chemical composition by gas chromatography. By agar diffusion method was evaluated inhibition of fungal growth of [i]Candida albicans [/i]and by tube dilution method to [i]Trichophytun tonsurans Trichophytun mentagrophytes[/i] and [i]Microsporun canis[/i]. [b][i]Results. [/i][/b]The following monoterpenes were found: pulegone, menthone, limoneno and myrcene. The muña essential oil completely inhibited [i]T. tonsurasn, T. mentagrophytes [/i]and [i]M. canis[/i] with both evaluation methods and doses, to [i]C. albicans[/i] was a inhibition zone diameters of 30 mm for the essential oil to 100 % and 35 mm to 50%. [b][i]Conclusions.[/i][/b] We showed the antifungal activity of muña essential oil, probably by the action of the monoterpenes found.
Authors and Affiliations
Carlos Cano, Pablo Bonilla, Mirtha Roque, Julio Ruiz
Keywords
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