In Vitro Antioxidant Properties of Novel Schiff Base Complexes
Journal Title: Asian Journal of Chemical Sciences - Year 2017, Vol 2, Issue 2
Abstract
Aim: In order to identify and evaluate the metal-derived synthetic antioxidants having high free radicals scavenging capacity related to various disorders has received much interest in last decades. Recently, synthetic antioxidants are widely used instead of natural antioxidants because they are effective and cheaper. Study Design: In the current investigation, a synthesized Schiff base ligand (2-{(E)-[(4-chlorophenyl)imino]methyl}phenol) and their metal complexes (Bis(2-{(E)[(4chlorophenyl) imino]methyl} phenol)nickel(II), Bis(2-{(E)[(4chlorophenyl)imino]methyl}phenol)Cobalt(II), Bis(2-{(E)[(4chlorophenyl)imino]methyl}phenol)copper(II), Bis(2-{(E)-[(4-chlorophenyl)imino]methyl}phenol) zinc(II)) have been evaluated in vitro for their possible antioxidant properties. Place and Duration of Study: Department of chemistry, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan. The experiment lasted for three days (72 hours). Methodology: The antioxidant activity of the synthesized compounds were screened by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), Ferrous ion chelation (FIC), Ferric reducing antioxidant power (FRAP), Total antioxidant activity (Phosphomolybdenum methods) and Hydroxyl radical (•OH) radical scavenging activity. Results: The synthesized compounds showed significant dose dependent antioxidant activities comparable with that of the classical antioxidants, ascorbic acid and ethylenediaminetetraacetic acid (EDTA). Conclusions: The compounds exhibited are very reactive towards DPPH radicals, OH radicals, and Fe+2 ions and it also actively reduces Fe(III) ion to Fe(II) and Mo(VI) ion to Mo(V) form. The ligand having moderate and all of the metal complexes were existed encouraging results which indicate the importance of Schiff base ligand a metal complexes as a source of synthetic antioxidants and possibly potent drugs.
Authors and Affiliations
Mohammad Ibrahim, Asif Khan, Muhammad Ikram, Sadia Rehman, Muzamil Shah, Hazrat Un Nabi, Ahamefula A. Ahuchaogu
Keywords
Related Articles
- EP ID EP338864
- DOI 10.9734/AJOCS/2017/32244
- Views 79
- Downloads 0
Phytochemical and Antimicrobial Studies of Maprounea membranacea Pax & K. Hoffm (Euphorbiaceae)
The aim of the present study was to carry out the isolation, purification and structural identification of secondary metabolites from methanolic extract of stem bark of Maprounea membranacea and further to evaluate the...
Ground State Electronic Energy and Ionization Energy of Atoms: Basis Free Density Functional Calculation
A new energy functional is proposed for basis free Density Functional Theory (DFT) calculation. Electronic density is calculated using atomic radii considering the atom as spherical. Ground- state electronic energies and...
XRD Studies, Spectral Characteristics, TGA and DFT of 2,4-Diamino-6-phenyl-1,3,5-triazine: Phenylthioacetic Acid Cocrystal
The title compound was prepared crystallizing together the co-formers namely, 2,4-diamino-6-phenyl-1,3,5-triazine (DAPT) and phenylthioacetic acid (PTAA) in methanol. The compound crystallized in the orthorhombic space g...
Effect of Thiourea Concentration on Structural, Optical and Electrical Properties of Cu2ZnSnS4 Thin Films Prepared by using Spray Pyrolysis
Thin films of Cu2ZnSnS4 (CZTS) with different molar concentrations of thiourea were prepared on glass substrates using spray pyrolysis technique. The structural, optical and electrical properties of the CZTS thin films w...
Study on Synthesis and Characterization of Hexaquonickel(II) bis-p-toluenesulfonate
Hexaquonickel (II) bis-p-toluenesulfonate [Ni(OTs)2•6H2O] was prepared from the reaction of p-toluenesulfonic acid (PTS) and nickel hydroxide [Ni(OH)2]. Energy disperse spectroscopy, thermal-analysis instrument, infrared...