In-Vitro Antitubercular Activity of Some Novel 6-Substituted/ Unsubstituted-2-Phenyl-Quinoline Derivatives
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 9
Abstract
With an objective to develop some potent, novel and less side effect having antitubercular agents here we have synthesized a series of substituted/ unsubstituted 2-phenyl tetrahydroquinoline derivatives (IIa-g). These were obtained by the reaction between substituted 2-phenyl-1, 2, 3, 4- tetrahydroquinoline and sulphur in acetonitrile. Structure of the newly synthesized compounds were confirmed on the basis of physico-chemical and spectral data (IR, 1H NMR, 13C NMR and Mass). All the synthesized compounds were screened for their antitubercular activity using Microplate Alamar Blue Assay (MABA) method. Among the synthesized compounds II b, II e and II g have shown significant antitubercular activity.
Authors and Affiliations
Pradeep Kumar MR, Rajesh D Hunashal
Keywords
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