In-vitro cholinesterase inhibitory activity of dry fruit extract of Phyllanthus emblica relevant to the treatment of Alzheimer’s disease
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 1
Abstract
Alzheimer’s disease (AD), a common type of progressive neurodegenerative disease, is characterized by low level of neurotransmitter (acetylcholine), oxidative stress and neuro-inflammation in brain stream. Effective treatment strategies rely mostly on either enhancing the cholinergic function of the brain by stimulating the cholinergic receptors, improve the level of acetylcholine from being a breakdown by cholinesterase enzymes or induce antioxidant therapy and anti-inflammatory agents. Phyllanthus emblica fruits are well known for its antioxidant activities with a rich source of vitamin C and polyphenols. A crude methyl extract (CME) of dry fruit of P. emblica evaluated for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity by Ellman’s method and were found active in inhibiting AChE and BuChE with IC50 of 53.88 µg/ml and 65.12 µg/ml respectively, which strongly implies that that the CME of P. emblica is a rich source of AChE and BuChE inhibitors.
Authors and Affiliations
Kushal Biswas, Md. Ariful Islam, Tahmida Sharmin, Pulak Kumar Biswas
Keywords
Related Articles
- EP ID EP49598
- DOI -
- Views 271
- Downloads 0
Fructose induces Antihyperlipidemic activity of dried leaves extract of Alternanthera brasiliana L. Kuntz. in Wistar rats
Objective of present study was to evaluate the Antihyperlipidemic activity of dried leaves extract of Alternanthera brasiliana L. Kuntz. We hypothesized that Alternanthera brasiliana L. kuntz dried leaves extract may b...
Cytotoxicity assessment of the stem bark of Tieghemella heckelii Pierre ex. A Chev. (Sapotaceae) towards Vero and RD human cancer Cell Lines
The present study aimed at investigating the cytotoxicity of the stem bark of Tieghemella heckelii Pierre ex. A Chev (Sapotaceae). For this purpose, plant extracts were put into contact separately with the different Ver...
TILIROSIDE: Biosynthesis, Bioactivity and Structure Activity Relationship (SAR) - A Review
Tilirosides (TLD) are glycosidic flavonoids (GFD) from originating in plants that exhibit a range of bioactivities of great interest for healthcare: antioxidant, anti-microbial, antifungal, anti-diabetic and antihyperli...
Comparing of antioxidant and DPPH induced free radical scavenging activity of Sesbania grandiflora and Acacia nilotica plants
Oxygen is a highly reactive atom that is capable of becoming part of potentially damaging molecules commonly called “free radicals.” Free radicals are capable of attacking the healthy cells of the body causing them to...
Indian antidiabetic plant used for the treatment of Hyperglycemia
Hypoglycemia is a chronic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. The global prevalence of diabetes is estimated to increase, from 4...