In vitro evaluation of transdermal permeation effects of Fu’s cupping therapy via six diffusion kinetics models
Journal Title: Traditional Medicine Research - Year 2019, Vol 4, Issue 1
Abstract
In this study, six kinetics models of indomethacin hydrophilic gel patch transdermal in vitro release was established, including zero-level, first-order, Higuchi-level, Ritger-Peppas, Weibull and Hixcon-Crowell dynamic equations. The chemical permeation enhancers, including 3% and 5% Azone, and iontophoresis were used as the control. Transdermal diffusion tests were performed in vitro and indomethacin was quantified by high performance liquid chromatography system. The transdermal parameter of the Higuchi and Weibull dynamic equations, indicated that Fu’s cupping therapy (FCT) could significantly improve Higuchi and Weibull kinetic parameters in vitro transdermal, increased transdermal rate and permeability coefficient, reduced lagging time. Additionally, statistical analysis speculated the skin barrier function could be restored after 46 h treatment. Hence, as a new physical transdermal drug delivery technology, transdermal permeation effects produced by FCT are obvious, which has the characteristics of traditional Chinese medicine and has important clinical application value.
Authors and Affiliations
Wei-Jie Xie, Yu-Mei Wu, Shuai-Shuai Chen, Jian Xu, Fang-Fang Yang, Yong-Ping Zhang, Xiao-Bo Sun
Keywords
Related Articles
- EP ID EP45170
- DOI 10.12032/TMR201915098
- Views 333
- Downloads 0
Explore the medication rules of Chinese medicine of Professor Huang Wenzheng for the treatment of chronic kidney disease based on data mining
The study found the backbone network and three-level network of the Chinese medicine for the treatment of CKD by homogeneous network analysis. The 5 top commonly used herbs were Dan Shen (Radix Salviae Miltiorrhizae) , F...
Ban Xia Lian Qiao Tang
Composition Jiang Ban Xia (Rhizome Pinelliae Fermentata) 30g, Lian Qiao (Fructus Forsythiae) 30g Directions The herbs are decocted with 500ml water and concentrated to 200ml. The patients between the ages of five a...
Tradition and Modern: Public Debate between Traditional Medicine Researcher and Philosopher
There have been disputes about traditional and modern medicine in the past hundreds of years continually since the recent western medicine was introduced into the eastern countries. The differences between the two system...
Molecular docking study on the molecular mechanism of rhaponticin for treatment of chronic myelocytic leukemia
Molecular docking can not only design drugs for the targets, but also detect mechanism of drug effecting on the targets. This study researched the interaction of rhaponticin and genes associated with chronic myelocytic l...
Network pharmacology-based approach to investigate the mechanism of Huang-Lian-Jie-Du-Decoction for treatment of type 2 diabetes mellitus
Background: Although the benefits of Huang-Lian-Jie-Du-Decoction (HLJDD) on type 2 diabetes mellitus are noted, the material base and action mechanism remain unknown. This paper aim is to reveal the material base and act...