IN VITRO FREE RADICAL SCAVENGING ACTIVITY OF AMORPHOPHALLUS COMMUTATUS AN ENDEMIC AROID OF WESTERN GHATS, SOUTH INDIA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
The aim of this study is to evaluate In vitro, antioxidant potential of five different solvent fractions of Amorphophallus commutatus tuber using multiple assays. The synthetic radicals DPPHo and ABTSo+ were scavenged effectively by the ethyl acetate fraction with IC50 value of 61.32±1.39µg and 69.6±1.1 µg respectively. Significant (p<0.05) radical scavenging was observed in the ethyl acetate fraction against radicals like super oxide, Nitric oxide, and Hydroxy with the IC50 values of 92.5±1.1 µg, 139.6±2.2 µg, 66.3±0.9 µg and 62.4±1.1 µg respectively. ABTSo+ scavenging of ethyl acetate was significant than BHT and other radicals were also scavenged significantly by ethyl acetate fraction. The results assure the presence of antioxidant principles in various fractions and among the fractions ethyl acetate showed significant activity.
Authors and Affiliations
Kavitha Krishna, Krishna Kumari, Vinodha M. , Anu Sebastin, Gomathi R.
Keywords
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