IN VITRO GLUCOSE BINDING ACTIVITY OF TERMINALIA BELLIRICA
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
Herbal medicine has become an integral part of standard healthcares based on a combination of time honored traditional usage and ongoing scientificscrutiny of their therapeutic potential and safety. The petroleum ether, chloroform, ethanol, and aqueous extracts of leaves, fruits, and bark ofTerminalia bellirica were evaluated for their effects on glucose adsorption, diffusion, and glucose transport across yeast cell. All the extracts could bindthe glucose effectively, and the glucose binding capacity was directly proportional to the molar concentration of glucose. The rate of glucose diffusionacross the membrane was found to increase from 30 to 180 minutes. The rate of uptake of glucose into the yeast cells was linear in all the five glucoseconcentration used in the study. Among the four extracts, ethanolic extract of leaves, fruits, and bark of T. bellirica show higher hypoglycemic activitywhile compared to other extracts. The hypoglycemic effect exhibited by the ethanol extracts of leaves, fruits, and bark is mediated by increasingglucose adsorption, glucose diffusion and glucose transport across the cell membrane as revealed by simple in vitro model of yeast cells.Keywords: Glucose adsorption, Glucose diffusion, Terminalia bellirica, Yeast cells.Â
Authors and Affiliations
Gayathri Devi S, Mary Shoba Das C
Keywords
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