In vitro Hemostatic Activity Screening of Sap of Jatropha Multifida L. (Euphorbiaceae) used in Traditional Medicine at Cotonou (Benin)
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 6
Abstract
This study has evaluated the hemostatic potential of Jatropha multifida’s sap as traditional medicine in Benin attributed hemostatic properties to this substance. Several hemostatic tests as Blood Coagulation Time, Quick Time, Activated Cephalin Time, Test of Milk Precipitation, Total Protein of blood samples were performed at 37°C. Prothrombin Time (PT) revealed prior to thromboplastin’s addition, there was precipitation of the plasma in all tubes except the control tube (T0). After addition of thromboplastin, control tube coagulated in 78 seconds while all other tubes were not coagulated (>15 minutes). The same observations were made for the Activated Cephalin Time (ACT) for which prior to addition of cephalin activator, there was precipitation of plasma in all tubes except the control tube (T0). After addition of cephalin activator, the control tube was coagulated with 43.33 seconds while test tubes were not coagulated (>15 minutes). Blood coagulation time decreased regardless of the administered dose of sap. Time of milk’s precipitation showed the sap rushes milk proteins. This was confirmed by the determination of total proteins in serum; proteins which decreased by over 60% with ¼ dilution for example (p<0.05). It has been proven that using sap of Jatropha multifida has some effects on hemostasis so its usage in traditional medicine is justified.
Authors and Affiliations
T. V. Dougnon , J. R. Klotoé , P. A. Edorh , J. Sègbo , J. M. Atègbo , O. A. Sodipo , T. J. Dougnon , C. Dandjesso , F. Loko , K. Dramane
Keywords
Related Articles
- EP ID EP93537
- DOI -
- Views 133
- Downloads 1
Effects of Extracts of Triplochiton Scleroxylon (K. Schum) on Plasma Glucose and Lipid Peroxidation in Normal and Streptozotocin—Induced Diabetic Rats
T. scleroxylon also known as ‘obeche’ and used in some of the rural areas in Nigeria in the treatment of diabetes mellitus was investigated in this study for lipid peroxidative activities. Plasma glucose and malondialdeh...
Effect of Lepidium sativum on Lipid Profiles and Blood Glucose in Rats
The present study was designed to investigate the effects of Lepidium sativum on the blood glucose and lipid profile in hypercholesterolemic rats. Fourty adult albino male rats were classified into three groups. One was...
Knowledge, Attitude, Practice and Determinants of Condom Use Among People Living With HIV/AIDS in Gondar University Hospital, North West Ethiopia
Condoms offer protection against unwanted pregnancy and some sexually transmitted infections including HIV. Interventions to promote condom use are essential in efforts to slow the spread of HIV. The burden of HIV/AIDS i...
Platinum Compounds-Induced renal and Bone Marrow Toxicity: a Review
Platinum compounds are widely used in cancer treatment despite of being highly toxic in nature. These platinum compounds share some structural similarities. However, there are marked differences between them in their the...
Monitoring Milk Urea Level and Feed Ration as a Potential Tool for Milk Quality
Milk quality appreciation parameters are not determined in Tunisia yet. Indeed, the variety of herds used, breeding systems and climatic conditions show a big variety of milk composition. The present study aims to quanti...