In Vitro Lethal Effect of Ellagitannins of the Fruit Rind of Punica Granatum and Stem and Root Alkaloids on The Miracidia and Cercariae of Schistosoma Mansoni
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Ellagitannins of fruit rind and alkaloids of the stem and root of Punica granatum (P. granatum) were investigated for their in vitro lethal effect on miracidia, and cercariae of Schistosoma mansoni (S. mansoni). All the three investigated constituents were lethal to both Schistosome larvae at concentrations ranging between 0.39-50 ppm. At 0.39 ppm of the tested active constituents, the killing time of 50% of Schistosoma larvae ranged between 30.0 to 135 min, and 43 to 380 min, for miracidia and cercariae, respectively. While stem alkaloids were generally more active against cercariae, root alkaloids were more effective against miracidia. At 3.125 ppm, the LT100 for cercariae and miracidia were respectively, 50 and 120 min for the stem alkaloids, and 300 and 30 min for root alkaloids. Ellagitannins were also more effective against miracidia than cercariae. At a concentration of 6.25 ppm, ellagitannins killed 50% of the cercariae and miracidia after 42 and 3 min, respectively. Ellagitannins could be prepared cheaply from pomegranate fruit rind which is produced in large amounts during the commercial production of pomegranate juice. Therefore, ellagitannins could be used as an affordable method for the control schistosomiasis.
Authors and Affiliations
Khalid H. Abu Zeid, Mohamed F. El-Badawy, Saad A. Gumaa, 4, Ahmed Ismael, Mohamed M. Shohayeb
Keywords
Related Articles
- EP ID EP387016
- DOI 10.9790/3008-1106048088
- Views 95
- Downloads 0
Sex hormones profiles in Iraqi males patients with symptomatic cholelithiasisbefore cholecystectomy
Gallstone disease (GD) is a worldwide disease and it remains to be one of the most common health problems leading to surgical intervention. GB stone formation is multifactorial &many theories have been put forwardto expl...
A Measure of Haemoglobin Instability in Individuals phenotyped as haemoglobin AC, SC and CC by Acetate Electrophoresis
One of the limitations in haemoglobin electrophoresis technique is the inability to distinguish between stable haemoglobin-C and unstable Haemoglobin-E. Haemoglobins A2, C, E and OArab migrate together during cellulose a...
The Using of BAT25 Marker for Detection of Microsatellite Instability in Malignant and Benign Breast Tumors
:Microsatellites are small DNA sequences repeat (1 to 6 base pairs in length) spread throughout the genome. Microsatellite instability (MSI) is the spontaneous loss or gain of nucleotides from repetitive deoxyribonucleic...
Effect of Gum Arabic on Liver Function And Antioxidant Enzymes of Sprague-Dawley Rats
The aim of this study was to investigate the effect of twelve weeks Gum Arabic dose on the liver functions and some antioxidant enzymes activity of 10 Sprague-Dawley rats. Methods: 10 normal Sprague-Dawley rats were fed...
Invitro Antimicrobial Activity And Phytochemical Analysis Of Murraya Koenigii Leaf Extracts
Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant based medicines, health products, pharmaceuticals, food supplements and cosmetics....