IN VITRO STUDY OF MICE LUNG TO SHOW THE BIOLOGICAL EFFECTS OF SMOKING
Journal Title: International Journal of Pharmaceutical and Biological Sciences Fundamentals (www.ijpbsf.com) - Year 2012, Vol 1, Issue 1
Abstract
The biological effects of smoking occur due to its interaction with nerve cells in the body and brain. Cigarette smoke is a complex mixture of chemicals. Some smoke components, such as carbon monoxide (CO), hydrogen cyanide (HCN), and nitrogen oxides, are gases. In this study, we focused our attention on the possible influence of acute term CS exposure on the induction of xenobiotic metabolizing enzymes in lungs of mice. At first, the histological analysis of lung revealed that the smoke exposed group showed emphysematous changes in the lung parenchyma with bronchi filled with mucus, however, the lung of animal treated with antioxidant, NAC, prior to cigarette smoke exposure showed a mild emphysematous change. This may be due to the inhalation exposure of smoke for short period of time, hence shows its effect on direct exposed organ like lung only. Moreover the oxidants induced by CS can directly damage components of the lung extracellular matrix such as elastin and collagen or even modify the matrix to make it more susceptible to protease attack importantly; acute smoke exposure did result in deleterious effect. The deleterious effect of CS in acute exposure is due to higher expression and activity/levels of oxidants than that of antioxidants. The delicate balance that exists between the toxicity of oxidants and the protective effects of intra and extracellular antioxidant defense systems is critical for the maintenance of normal function. This study further contributes to the understanding of the deleterious effects of acute-term exposure of CS in lungs.
Authors and Affiliations
Vijay Laxmi
Keywords
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