In-Vivo anthelmintic Activities of Ethanol Extract of Croton (Codiaeum variegatum L. Blume) Against Tapeworm Hymenolepis microstoma
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 2
Abstract
As per reported in a previous study, the extract of the croton twig possesses an anthelmintic activity against the Hymenolepis spp cestode in an in Vitro model. The aim of the present study was to determine the anthelmintic activity of the croton twig extract against the tapeworm Hymenolepis microstoma in Vivo. The study was started out by experimentally infecting mice with H. microstoma. Infected mice were divided into five groups consisting of one control negative group, one control positive group, and three test groups of three different doses; 125, 250, and 500 mg/kg BW. Evaluation was carried out by the fecal egg count reduction (%FECR) and the worm count reduction. Statistical analysis showed that all test group have lower egg per gram count and lower worm count than that of the control negative group. Result showed at dose 125 mg/kg BW, the croton twig extract has the highest ability to reduce the number of eggs with an %FECR of 63,25%, whilst the highest ability of reducing the number of worms was shown by the extract at dose 500 mg/kg with a %WCR of 63%.It is suggested that further works including safety, effective dose need to be carried out before using twigs C.variegatum as anthelmintic agent. Keywords: Anthelmintic, Codiaeum variegatum, tapeworms, Hymenolepis microstoma
Authors and Affiliations
Gofarana Wilar, Sri Agung Fitri Kusuma, Yusuf Ridwan, Fairuz Amni
Keywords
Related Articles
- EP ID EP377436
- DOI -
- Views 95
- Downloads 0
Computer aided screening of natural products in search of lead molecules for design and development of potent anti-inflammatory agents
The aim of this study was to examine correlation between anti-inflammatory activity and molecular properties of the ten selected natural products in search of a lead compound through Molinspiration, Osiris and PASS chemi...
A review on Herbal Excipients and their pharmaceutical applications
The Herbal or natural excipients have a great advantage over their synthetic analogues as these are non-toxic, less expensive and freely available. The increasing awareness about these herbal excipients, which are manly...
Drug-Excipient Interaction Study of Lornoxicam with Polymers
Interaction study is the most important step in reformulation study for the preparation of all dosage forms. The interaction can affect physical, chemical, therapeutic and biological properties and stability of drug and...
Management and Role of diet and exercise in diabetes mellitus: A Review
Diabetes is chronic hyperglycaemia together with other metabolic abnormalities. It is due to insulin resistance or deficiency as well as increased output of hepatic glucose. It is a risk factor for CVD. Currently there i...
Anti-allergic activity of dichloromethane extract and related lignans from Magnolia biondii Pamp.
The objective of present study is to evaluate the effect of anti-allergic activity of dichloromethanolic extract and related lignans from Magnolia biondii Pamp. Dried flower buds of Magnolia biondii were collected in Chi...