In vivo antiplasmodial activity of crude extracts of Vernonia cinerea Less (Asteraceae) against Plasmodium berghei infection in mice in Bobo-Dioulasso, Burkina Faso.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 4
Abstract
Resistance of Plasmodium falciparum against antimalarial drugs constitutes a veritable obstacle to malarial control in the world and particularly in Sub-Saharan Africa. Nowadays the artemisinin resistance was observed in the South-east Asian region. Several investigations were made on the medicinal plants species coming from Asteraceae family above all Vernonia cinerea Less and were showed that the plant own several pharmacology activities tested in pre-clinical trials. The plant material was collected in Banfora (Burkina Faso). The antiplasmodial activity of the 80% methanolic extract, 50/50 % hydro-methanolic and aqueous extract have been tested against Plasmodium bergheiin mice by using the Peter’s 4-day suppressive test was conducted. The NMRI female mice have been used and treated with the distilled water, 100, 250, and 500 mg/kg body weight of the extract, respectively. Percentage of parasitaemia and parasitaemia suppression were determined. The standard deviation and the IC95 were calculated. The analyzes were made by the Excel software and ANOVA. The results revealed 21.4 %; 13.8 % and 43.1 % (p>0.05) inhibition at 100, 250 and 500 mg/kg bwt dose levels, respectively by the 80 % methanolic extracts. The 50/50% hydro-methanolic extracts showed a percent reduction of parasitemia of 42.7 %; 25.6 % and 40.6 % (p>0.05) respectively for the same dose levels. About the aqueous extracts, the suppression produced 9.5 %, 14.6 % and 3.2 % (p>0.05) at 100, 250 and 500 mg/kg bwt dose levels, respectively.These results suggest that the extract of Vernonia cinerea Less possesses antiplasmodial activity and these results may justify its use in ethnomedicine to treat malaria disease.
Authors and Affiliations
Seydou SOURABIE, Aboubakar SOMA, Serges R. YERBANGA, Léa N. BONKIAN2, Benjamin K. KOAMA5, Mamoudou CISSE, Gordon A AWANDARE4, Noufou OUEDRAOGO1, Jean-Baptiste NIKIEMA6
Keywords
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