IN VIVO HEPATOPROTECTIVE EFFECT OF CAFFEIC ACID ON MERCURIC CHLORIDE-INDUCED BIOCHEMICAL CHANGES IN ALBINO WISTAR RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 4
Abstract
Objective: Mercury (Hg) is a highly dangerous and also one of the harmful heavy metals which induces oxidative stress in the animal body. The present study is planned to examine the possible defensive result of caffeic acid (CA) against mercury chloride (HgCl2)-induced hepatotoxicity in male albino Wistar rats, Rattus norvegicus. Methods: Sublethal dose of HgCl2 (1.29 mg/kg body weight) was administrated in rats for 15 days through oral dose and the CA was administrated for another 15 days on mercuric-intoxicated rats. After completing the scheduled exposure time, the rats were sacrificed and the whole liver organ was removed immediately from the animal, and it was used to carry out for biochemical and bioenzymological studies to observe. Results: The level of lipid peroxidation (LPO) content reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the liver tissue. CA is an energetic component in the phenolic propolis extract and also in a wide variety of plants, and a strong antioxidant helps to prevent oxidative damage and to reduce oxidative stress. The antioxidants such as GPx, CAT, and SOD and non-antioxidant GSH were significantly decreased, and also, the LPO level was increased in mercury toxicity rats. The treatment of CA (5 mg/kg body weight) in the liver tissue shows considerable declining in the level of oxidant content and along with an increase in the level of antioxidant properties by the way of improvement in liver tissues. Antioxidant and non-antioxidant enzyme (LOP, GSH, GPx, SOD, and CAT) activities were also significantly decreased to near untreated control level when compared to Hg-treated group. The CA acid alone treatment showed the enhanced antioxidant levels and not any alteration in the levels of biochemical parameters when compared with control. Conclusion: These observations of the present experimental study clearly explained the detoxify effects and protective effect of CA against HgCl2 toxicity in liver tissue.
Authors and Affiliations
MANOGARAN MANJU , GANESAN JAGASEESAN
Keywords
Related Articles
- EP ID EP604666
- DOI -
- Views 115
- Downloads 0
FORMULATION AND EVALUATION OF IN-SITU GEL CONTAINING CIPROFLOXACIN HYDROCHLORIDE IN THE TREATMENT OF PERIODONTITIS.
Objective: The present study describes the use of in-situ gel in periodontal drug delivery systems which contains gellan gum (0.4–0.6% w/v), pluronic F127 (14, 15 and 16% w/v), and drug Ciprofloxacin HCl (0.1% w/v). Nu...
ANTI-ATHEROSCLEROTIC ACTIVITY OF ELAEOCARPUS GANITRUS ROXB. IN CHOLESTEROL-FED RABBITS
  Objectives: Atherosclerosis was experimentally induced in New Zealand white male rabbits by cholesterol feeding for 120 days for investigating effects of 70% ethanolic Elaeocarpus ganitrus seed extract (EEGS) against...
NANOSTRUCTURED LIPID CARRIERS: THE FRONTIERS IN DRUG DELIVERY
By the modification of solid-lipid nanoparticles (SLNs), the nano-structured lipid carriers (NLCs) were obtained by the modification of nanostructured that hold the qualities of the SLN, increases the stability of the dr...
ANTI-ULCER ACTIVITY OF HYDROALCOHOLIC EXTRACT OF PIPER BETLE LEAF ON EXPERIMENTAL ANIMALS
Objective: The main objective of this study is to establish the anti-ulcer activity of hydroalcoholic extract of Piper betle leaf on experimental animals based on previously existing aspects such as antioxidant, antihist...
FORMULATION AND IN VITRO IN VIVO EVALUATION OF BOSENTAN PELLETS FOR PROLONGED DRUG RELEASE
Objective: The objective of this study was to develop extended release (ER) pellets of Bosentan, an endothelin receptor antagonist using fluid bed processor (coating).Method: The ER drug pellets of Bosentan were prepared...