IN VIVO – IN VITRO CORRELATION – A STRATEGIC TOOL FOR DRUG DEVELOPMENT
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 10
Abstract
Development and optimization of formulation is an integral part of manufacturing and marketing of any therapeutic agent, which is a time consuming and costly process. Correlation between In Vivo – In Vitro (IVIV) data is often used after proper validation. It predicts the bioavailability results from in vitro dissolution. In this paper, we have described an in vitro advanced gastric model to study the behavior of oral compounds under interactive kinetic conditions in the human stomach. This model simulates the motility and pressure forces in the different regions of stomach, the rate and composition of gastric secretion fluid. IVIVC is a mathematical model, among all the three levels of correlation Level A is widely accepted by regulatory agencies.
Authors and Affiliations
Sunisha Kulkarni
Keywords
Related Articles
- EP ID EP618996
- DOI -
- Views 142
- Downloads 0
COMBINED TREATMENT WITH ALPHA- TOCOPHEROL PREVENTS SIMVASTATIN - INDUCED SKELETAL MUSCLE INJURY IN RATS
Statins are widely used regardless of their myopathic side effects that ranging from weak myalgia to serious rhabdomyolysis. Simvastatin is one of the most common used of all statins anti-hyperlipidemic drugs despite the...
A REVIEW ON PRESCRIPTON AFTER MYOCARDIAL INFARCTION, DOSAGE AND PERSISTENCE
Myocardial infarction is one of the most common forms of CAD. The morbidity and mortality rate is very high due to MI. Beta-blockers, angiotensin-converting enzyme (ACE)-inhibitors and statins are widely recommended for...
CLINICAL, HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF MALIGNANT BRENNER TUMORS OF OVARII. REVIEW AND CASE REPORT
Brenner Tumor (BT) is a relatively uncommon neoplasm, accounting 1- 2% of all ovarian neoplasms, identified in 1907 by Fritz Brenner. Most BTs are benign. Malignant BTs are extremely rare, comprising < 5 % of all ovarian...
EVALUATION OF ACTIVATED LEUCOCYTE CELL ADHESION MOLECULE IN HEPATOCELLULAR CARCINOMA PATIENTS
Background: Besides, cost/effectiveness and efficacy of surveillance and screening of patients with cirrhotic liver for the diagnosis of hepatocellular carcinoma (HCC) is still debated. Search for suitable biomarkers of...
RAPID AND SPECIFIC DIAGNOSIS OF BACTERIAL SEPSIS IN HIGH RISK PATIENTS
Sepsis is a major healthcare problem worldwide, athe accurate and timely detection of sepsis remains a challenge specially in high risk patients as blood culture and sensitivity testing results are slow and delay the beg...