IN–VITRO ANTI-CANCER STUDY OF BIOTRANSFORMED MATERIAL (EXTRACT) OF CALENDULA OFFICINALIS BY MTT ASSAY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: This work aims to determine the in-vitroanti-cancer activity of biotransformed material (extract) of calendula officinalisflowers.Methods: Various concentrations of the biotransformed material (extract) of calendula officinalis were tested. The MTT assay method was used using A549 cell lines, LN Cap-FGC cell linesand MDA-MB cell lines.Results: The result shows promising effect of biotransformed material (extract) of calendula officinalis. The IC50 values were found to be less than10 µg against A549 cell lines, the activities against LN Cap-FGC cell lines were found to be 10 µg and IC 50 values were found to be 10 µg against MDA-MB cell linesConclusion: From this study it was evident that the cancer cell growth was significantly inhibited by treatment with biotransformed material (extract). Hence, in vitro studies of Calendula officinalis was found to have a potential anti-cancer activity.Â
Authors and Affiliations
Ashlesh Vishodhan Murkute, Ashlesh Murkute
Keywords
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