Incidence and Association of Glycated Hemoglobin Levels with Iron Deficiency Anemia in Patients with or without Diabetes – A Study in a Semi Urban Area
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: HbA1c and other hemoglobins constitute the HbA1 fraction of the adult HbA3. HbA1c is also affected by pregnancy5,6, uremia7, hemolytic anemia8, hemoglobinopathies9, acute and chronic blodd loss10,11, Vitamin B12, folate deficiencies. Iron deficiency anemia is also shown to have a considerable effect on HbA1c levels12. Studies have shown that reduced iron levels are correlated with increased levels of HbA1c leading to false high levels of HbA1c in individuals. Materials and Methods: 1000 patients each with and without diabetes were included into the study. Hemoglobin levels, meancorpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MHCH), mean corpuscular volume (MCV),hematocrit, platelet count, total blood picture, differential leucocyte count was done for all samples. Samples from patients withIDA were tested for all the above parameters at base line, after 1 week, 1 month and 2 months following iron treatment. Type ofanemia was categorized and mild moderate and severe based on hemoglobin levels. Results: Preponderance of females were seen in the anemic cases over males. 11.1% of non-diabetic and 16.3% of the diabeticpatietns were anemic. The prevalence of low hemoglobin and low iron content was seen in 2.8% of the cases among nondiabeticswhile low Hb and normal iron levels were seen among 4.6% of the cases. Normal Hb with iron deficiency were seenamong 3.7% of the cases while among the diabetics it was 2.1%, 7.3% and 6.9% respectively. Mean hemoglobin levels of all thesevere anemic patients at base line was 5.9 ± 1.2, 9.1 ± 0.9 after 1 month and 10.6 ± 1.5 after 2 months of treatment. Conclusion: There is a significant association of HbA1c levels and Iron Deficiency Anemia according to our study, though morestudies need to be conducted to assess a proper clinical diagnosis
Authors and Affiliations
Nasika Chowdeswari, N. Jaya, B. V Rama Rao
Keywords
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