Incidence of thyroid dysfunction and hypothyroidism induced hypercholestremia among the patients in Nobel Medical College Teaching Hospital, Biratnagar, Nepal
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 4
Abstract
Background: Disorders of thyroid function is very much known to influence the metabolism of lipids associated mostly with increased level of cholesterol in the body. Hypothyroidism has an adverse effect on the serum lipid profile that may be a predisposing factor to the development of atherosclerotic disease, which again contributing to the establishment of cardiovascular disease (CVD). Objectives: To screen the patients suffering from the disorders of thyroid hormone and to elicit the relation of increased total cholesterol level in the blood in case of hypothyroidism. Material and Methods: A total of 762 patients were screened for thyroid dysfunction by estimating free triiodothyronine-3 (fT3), free thyroxine-4 (fT4), Thyroid Stimulating Hormone (TSH) along with the level of total cholesterol in the blood samples collected from those patients attended Nobel Medical College OPD in between 1st March 2013 to 31st January 2014 and recruited for this study after Institutional ethical approval. Serum samples from these patients were tested for fT3, fT4 & TSH level by Chemiluminescence Immunoassay (CLIA). The total blood cholesterol was estimated by CHOD/PAP method. Mean value and standard deviation were calculated using Student’s two–tailed t–test. Analysis of data was performed using one–way ANOVA. Results are considered statistically significant if p ≤0.05. Results: Out of 762 patients, 20.2% were hypothyroid, 15.09% were hyperthyroid and 64.69% were euthyroid. Out of all cases of hypothyroidism, 63.63% of patients were female where as 36.36% were male patients. Similarly, out of the total patients suffering from hyperthyroidism, 70.43% were of female and 29.56% were of male. Total cholesterol level (304±63) was found to be significantly elevated in those blood samples collected from the group having hypothyroidism than those of euthyroid group (p=0.05). Conclusion: The present study provides the information about the prevalence of thyroid disorder among the population of Biratnagar, eastern Nepal. It also elicits that the total cholesterol level is highly increased among the patients associated with hypothyroidism, likely to be a potential factor contributing to cardiovascular disease in this group.
Authors and Affiliations
Rupesh Kumar Shreewastav*| Department of Biochemistry, Nobel Medical College Teaching Hospital, Chandra Prakash Gaire| Department of Biochemistry, Nobel Medical College Teaching Hospital, Prashant Kumar Shah| Department of Biochemistry, Nobel Medical College Teaching Hospital, Arambam Giridhari Singh| Department of Biochemistry, Nobel Medical College Teaching Hospital
Keywords
Related Articles
- EP ID EP3735
- DOI -
- Views 453
- Downloads 24
Coxsakie B virus among type 1diabetic Sudanese children
Background: Type 1 diabetes is characterized by autoimmune destruction of pancreatic beta cells. Infection by Coxsackievirus B virus has been linked to the onset of type 1 diabetes; however its precise role has not been...
A REVIEW ON ACNE
Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non inflammatory (comedones, op...
Cassia Javanica Linn: A Review on Its Phytochemical and Pharmacological Profile
Cassia javanica Linn is a small and medium sized tree with widely spreading horizontal branched and shows blossoms. Native to the tropical regions of Asia, Java Cassia is distributed naturally from India to Malaysia, Sum...
Impact of Calcium-Vitamin D Supplements on the Dissolution Pattern of Ranitidine Hydrochloride Tablets: An in vitro Dissolution Study using UV Spectroscopy
The objective of this study was to evaluate the impact of Calcium-Vitamin D supplement formulations on the dissolution pattern of different Ranitidine Hydrochloride tablet formulations. This was an in-vitro dissolution s...
STUDY ON DISSOLUTION IMPROVEMENT OF ALLOPURINOL BY CO-GRINDING AND FUSION METHOD USING SOLID DISPERSION TECHNIQUE
Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with treatment of diureticconditions. One of the major problems with the drug is that it is practically insoluble in wat...