Increasing the Probability of Discovering Improved Antiepileptic Drugs through the Use of Human Epileptic Tissue
Journal Title: Archives of Pharmacy & Pharmacology Research - Year 2018, Vol 1, Issue 2
Abstract
Epilepsy affects millions of people world-wide with wide-ranging health and economic consequences [1]. A first-line approach to the control of epilepsy is through the administration of anticonvulsant drugs sometimes referred to as antiepileptics [2]. These medicines help control seizure activity but the evidence for controlling disease progression in patients is not firmly established [3]. There are many antiepileptics approved for clinical use [2] that dampen excitatory neurotransmission through different mechanisms including positive allosteric modulation of GABA (e.g., diazepam, valproic acid) and blockade of ion channels (e.g., gabapentin, lacosamide).
Authors and Affiliations
Keywords
Related Articles
- EP ID EP593839
- DOI 10.33552/APPR.2018.01.000510
- Views 38
- Downloads 0
Level of Micronutrient [Zinc] and its Association with Seizures in Children: A Case Control Study
Objective: To determine the levels of serum zinc in children with febrile seizures when compared to children with fever without seizures and compare the levels of serum zinc in children with seizure due to CNS with febri...
Increasing the Probability of Discovering Improved Antiepileptic Drugs through the Use of Human Epileptic Tissue
Epilepsy affects millions of people world-wide with wide-ranging health and economic consequences [1]. A first-line approach to the control of epilepsy is through the administration of anticonvuls...
Role of Psychiatry Nurse in Anti-Manic Drugs
Anti-manic drugs are the mood stabilizers that are used to treat mania. There are various types of drugs which are prescribed for anti-manic affect. There is need for the various observations like physiological changes t...
A Charge Transfer Determination of Paracetamol with Picric Acid
A cost effective and sensitive spectrophotometric method has been developed for the assay of paracetamol in pure and commercial forms. The method employed was charge transfer complexation. Para...
Perception of Over the Counter Drug Advertising among Pharmacists in Abu Dhabi, UAE
Objectives: The aim of this study was to investigate pharmacists’ perception and attitude towards OTC drug advertising in Abu Dhabi, UAE. Study design: A cross-sectional study. Methods: A pre-piloted 35-item questionna...