Incretin mimetics: new age drugs for type 2 diabetes mellitus
Journal Title: Pakistan Journal of Pharmacology - Year 2012, Vol 29, Issue 2
Abstract
Type 2 diabetes mellitus is a fast growing global epidemic and its prevalence has increased in the 21st century. The rise in blood glucose levels is associated with complex pathogenesis which includes a significant reduction of the incretin effect. In patients with type 2 diabetes, glucagon like peptide-1 secretion may be impaired. In depth understanding of the role of incretin hormones in glucose homeostasis has led to the development of incretin-based therapies that target gastrointestinal hormone action of incretin and cause significant glucose-lowering effects, promote weight loss (or are weight-neutral), inhibit glucagon secretion and protect beta cells. They represent a new tool to be used as an add on therapy to older ant diabetic drugs which by themselves have not been successful in retarding the progression of the disease.
Authors and Affiliations
Deepika Tikoo, Meenakshi Gupta
Keywords
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