Independent predictors of coronary artery disease through computed tomography coronary angiography
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 7
Abstract
Objective: To investigate the presence coronary artery lesions, atherosclerotic plaque characteristics, coronary artery disease (CAD) extension and coronary artery calcium score in normotensive and hypertensive patients, using computed tomography coronary angiography (CTCA). Methods and Results: Patients with low and intermediate risk CAD were recruited at the Dante Pazzanese Institute of Cardiology, Sao Paulo, Brazil. Hypertensive (HT, n = 305) and normotensive (NT, n = 137) patients, 233 men (52.7%), 30 to 90 years old. CTCA-detected CAD was more prevalent in HT (63.6%) than in NT patients (48.9%, p=0.004). Coronary artery lesions (≥ 3 vessels), significant stenosis (≥ 50%), atherosclerotic significant segments (≥ 50%), calcified plaques were more frequent in HT when compared to NT group (p<0.05). Frequency of low CACS (0) was higher in NT (51.8%) than in HT (32.0%) patients (p=0.02), but no differences were observed in high CACS (≥ 100) between these two groups (p>0.05). Age, male gender and dyslipidemia were independent predictors for coronary significant stenosis, atherosclerotic significant segments, multi vessel involvement, high CACS and calcified plaque (p<0.05). Moreover, these variables and diabetes mellitus are predictors of calcified plaques (p<0.05). Conclusion: CTCA variables and calcium score are useful tools to evaluate the extent and magnitude of coronary artery lesions, independently of risk factors for CAD
Authors and Affiliations
Joselina Luzia Menezes Oliveira, Mario Hiroyuki Hirata, Irlaneide da Silva Tavares, Enaldo Vieira Melo, Amanda Guerra de Moraes Rego Sousa, Antonio Carlos Sobral Sousa, Daniel Pio Oliveira, Luciano de Figueiredo Aguiar-Filho, Luiza Dantas Melo, Thiago Dominguez Crespo Hirata, Vítor Joaquim Barreto Fontes, Fabiola Santos Gabriel, Carlos José Oliveira de Matos, Ibraim Masciarelli Francisco Pinto
Keywords
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