Independent release behavior of Glipizide matrix release tablets containing chitosan and xanthan gum

Abstract

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of Glipizide (G) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. The release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also exhibited pH and buffer species dependent release. In contrast, the HME tablets containing both chitosan and xanthan gum exhibited pH and buffer species independent sustained release. When placed in 0.1N HCl, the HME tablets formed a hydrogel that functioned to retard drug release in subsequent pH 6.8 and 7.4 phosphate buffers even when media contained high ionic strength, whereas tablets without chitosan did not form a hydrogel to retard drug release in 0.1N HCl.

Authors and Affiliations

T. Ramanji reddy* , Dr. D. Dhachinamoorthi , Dr. K. B. Chandrasekhar

Keywords

Related Articles

Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Domperidone and Rabeprazole Sodium in Bulk and Dosage Forms

The use of first order derivative spectroscophotometry allowed simultaneous determination of domperidone and rabeprazole sodium, in fixed dose combination products. The absorbance values at 253.2 nm and 266.4 nm of first...

Validation of a novel Spectrophotometric methods for estimation of Deferasirox

A simple, novel and sensitive spectrophotometric method was developed for the determination of Deferasirox1-3 (DFX) in bulk and in pharmaceutical formulations. The method is based on Reduction of the drug in the presence...

Independent release behavior of Glipizide matrix release tablets containing chitosan and xanthan gum

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of Glipizide (G) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt ext...

FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM OF NIFEDIPINE HYDROCHLORIDE USING MULTI-UNIT CHITOSAN TREATED ALGINATE

The main objective of the present work was to develop sustained release matrix tablets of water soluble Nifedipine hydrochloride using multi-unit chitosan treated alginate. Sustained release formulation is the drug deliv...

Stomach Specific Mucoadhesive Tablets As Controlled Drug Delivery System – A Review Work

Stomach-specific mucoadhesive tablets as a controlled drug delivery system have been developed to increase gastric retention time of the dosage forms. This article presents the polymers use for mucoadhesive tablets, fact...

Download PDF file
  • EP ID EP155424
  • DOI -
  • Views 106
  • Downloads 0

How To Cite

T. Ramanji reddy*, Dr. D. Dhachinamoorthi, Dr. K. B. Chandrasekhar (2010). Independent release behavior of Glipizide matrix release tablets containing chitosan and xanthan gum. International Journal of Pharmaceutical and Biological Research, 1(2), 64-70. https://europub.co.uk/articles/-A-155424