Indicators of cellular immunity in case of рassalurosis of rabbits

Abstract

Introduction. Researching the characteristics of immunity is the best way to effective prevent and treat the diseases. Helminthiasis immunity has a number of features that are caused by relationships in the host-parasite system. Passalurosis is quantitatively dominant among many types of rabbit helminths on the globe. The goal of the work was to determine the influence of Passalurus ambiguus on indicators of cellular immunity of rabbits. Materials and methods. Analog groups of male rabbits of 3-5 months old were selected for the experiments. Intensity of invasion was determined by the method of the Mac-Master. The count of T- and B-lymphocytes was determined by the method of spontaneous rosette-formation with sheep erythrocytes. Rabbits with pasalurosis had different levels of invasion intensity (II): low (II = 276.47±43.33 eggs in 1 g of feces), high (II = 2446.67±422.11 eggs in 1 g of feces) – II and medium (II =1293.75±275.80 eggs in 1 g of feces) – III research groups. We did not find helminth’s eggs in the control group. Results of research and discussion. It was found that in the blood of rabbits with pasalurosis in groups I, II, and III, compared with healthy ones, there was significantly high number of lymphocytes by 11.48% (p <0.05), 17.37% (p <0.01), 11.31% (p <0.05), due to both B-lymphocytes (1.74 times (p <0.001), 1.96 times (p <0.001), 2.20 times (p <0.001), T-lymphocytes (1.17 times (p <0.05), 1.22 times (p <0.001), 1.28 times (p <0.001)), against the background of a low percentage of O-lymphocytes by 13,81% (p <0.001), 15.22% (p <0.001), 16.83% (p <0.001). Probably the increased number of T-lymphocytes in infected animals was observed in rabbits with a high content of T-helpers in the blood, which were 1.25 times (p <0.01), 1.41 times (p <0.001) and 1.60 times (p <0.001) higher compared with the control group. In addition, the total number of T-active blood lymphocytes was 1.37 times (p <0.01), 1.54 times (p <0.001), and 1.74 times (p <0.001) higher, respectively, in animals of the І, II and III groups than in the control one. Such a change in the subpopulation composition of T-lymphocytes indicated the activation of the protective mechanisms of the rabbit organism in response to mechanical damage to the epithelium and metabolic products of the pathogen Passalurus ambiguus. Conclusions. In general, the results of studies showed that effect of the pathogen Passalurus ambiguus in the blood of rabbits leaded to an increase in T- and B-lymphocytes, T-helper cells and T-active ones, against the background of a decrease in О-lymphocytes. Such redistribution of lymphocyte populations is an immune response to parasitism of рassalurіs.

Authors and Affiliations

Y. V. Duda, M. P. Prus

Keywords

Related Articles

Some epidemiological aspects of rabies in animals in the Republic of Moldova

Introduction. Rabies is absolutely incurable disease. Path rabies infection from one animal to another or from animals to humans occurs directly through the bite or scratch derived from sick animals. Prevention of rabies...

Comparative description of epizootic and epidemic situation on salmonellosis in L’viv oblast

Introduction. The article concerns a comparative study of epizootic and epidemic situation on salmonellosis in Lviv oblast during the last decade. In Lviv oblast, during 2008–2017, the aggravation of the epidemic situat...

Toxicological and biological evaluation of broiler-chickens products at farmazyn and tylotsyklinvet application

Introduction. Currently, in the European Union countries, as well as in Ukraine, the ban on the use of fodder antibiotics and hormonal drugs, as growth stimulators for animals, including broiler chickens, was introduced....

Micromycetes species identification and study of their ability to produce fusariotoxins

Introduction. Among many toxic environmental factors, more attention is attracted to the metabolites of mold fungi - micotoxin. More than 45 of only trichothecene mycotoxins have been isolated and studied. T-2 toxin is o...

The technology for producing marine hydrobiont feed additives for the poultry, their fodder value and sanitary evaluation

Introduction. Ukraine is a maritime state with a significant raw material base of sea hydrobionts, among which bivalve mollusks – mussels and algae – Phyllophora nervosa, are of industrial importance. In modern condition...

Download PDF file
  • EP ID EP659987
  • DOI 10.31073/vet_biotech35-05
  • Views 135
  • Downloads 0

How To Cite

Y. V. Duda, M. P. Prus (2019). Indicators of cellular immunity in case of рassalurosis of rabbits. Бюлетень "Ветеринарна біотехнологія", 35(), 35-44. https://europub.co.uk/articles/-A-659987