Indicators of renal fibrosis in children receiving conservative treatment for chronic kidney disease

Journal Title: Medycyna Ogólna i Nauki o Zdrowiu - Year 2013, Vol 19, Issue 1

Abstract

[b][/b]Background and Objective. Matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), adhesion molecules and heat shock proteins (hsp) may play an essential role in the process of renal fibrosis, but the data concerning such influence in the patients with chronic kidney disease (CKD) on conservative treatment are scarce. The objective of the study was to assess the concentrations of Hsp90a, sE-selectin, MMP-2, TIMP-1 and TIMP-2 in the predialysis CKD children and potential relations between these parameters.Material and methods. 65 children were enrolled in the study and divided into those with CKD stage 3-4 (CKD I) and CKD stage 5 (CKD II). 30 age-matched subjects with primary nocturnal enuresis and normal kidney function served as controls. The serum concentrations of Hsp90a, sE-selectin, MMP-2, TIMP-1 and TIMP-2 were assessed by ELISA.Results. The median values of Hsp90a, sE-selectin, MMP-2, TIMP-1 and TIMP-2 were significantly elevated in CKD patients vs. controls. The concentrations kept growing together with the progressing renal failure in the case of sE-selectin and MMP-2, remained unchanged in the case og TIMP-1 and TIMP-2, whereas diminished in the case of Hsp90a. Several correlations between examined parameters were noticed.Conclusions. The increased concentrations of Hsp90a, sE-selectin, MMP-2, TIMP-1 and TIMP-2 indicate the enhanced cell damage, aggravation of inflammatory and proteolytic processes, responsible for progression of interstitial renal fibrosis in CKD children. Differences in behaviour of selected parameters in the course of renal failure progression suggest the diversity of their engagement in various stages of CKD.Key words: Hsp90a, sE-selectin, MMP-2, TIMP-1, TIMP-2

Authors and Affiliations

Kinga Musiał, Danuta Zwolińska

Keywords

Related Articles

Jakość życia chorych na stwardnienie rozsiane a stopień niesprawności ruchowej – doniesienie wstępne

[b]Wprowadzenie i cel pracy.[/b] Stwardnienie rozsiane (SM) jest jedną z najczęstszych przewlekłych i nieuleczalnych chorób neurologicznych rozpoznawanych między 20. a 40. rokiem życia. Etiologia schorzenia nie została d...

Imaging in the diagnostics of low back pain

Diagnostic work-up of low back pain (LBP) is often characterized by overimaging. Abundance of information retrieved from images may sometimes be misleading and result in diagnostic pitfalls. The purpose of this review i...

Folic acid – effects of deficiency and justification for supplementation

Folic acid belongs to the group of vitamins B soluble in water. It plays an important role in many metabolic processes, and the effects of its deficiency are health and life threatening. The supply of the amount of fola...

Orthorexia in a group of dietetics students

[b]Introduction[/b]. Ortorexia is defined as an excessive preoccupation with healthy food, preparation of meals according to strict rules, and subordination of life to the restrictive diet. [b]Aim.[/b] The aim of this...

Pourazowe obrażenia czaszkowo-mózgowe u pacjentów w stanie nietrzeźwości, przyjmowanych doraźnie do szpitalnego oddziału ratunkowego

[b]Wstęp. [/b]Alkohol etylowy uznawany jest za jeden z najważniejszych czynników ryzyka prowadzących do powstawania urazów czaszkowo-mózgowych. Wśród pacjentów przyjmowanych do Szpitalnego Oddziału Ratunkowego (SOR) dużą...

Download PDF file
  • EP ID EP68940
  • DOI -
  • Views 59
  • Downloads 0

How To Cite

Kinga Musiał, Danuta Zwolińska (2013). Indicators of renal fibrosis in children receiving conservative treatment for chronic kidney disease. Medycyna Ogólna i Nauki o Zdrowiu, 19(1), 41-44. https://europub.co.uk/articles/-A-68940