INDUCIBLE CLINDAMYCIN RESISTANCE IN ERYTHROMYCIN-RESISTANT STAPHYLOCOCCUS AUREUS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 18
Abstract
BACKGROUND The ERM gene product confers clindamycin resistance on Staphylococcus aureus. Clindamycin susceptible, erythromycin-resistant Staphylococcus aureus (Clindamycin-Erythromycin Discordant) may develop clindamycin resistance. Clindamycin is commonly used in the treatment of erythromycin-resistant S. aureus causing skin and soft infections. This led us to demonstrate a very simple method of detecting inducible resistance to Clindamycin in erythromycin-resistant S. aureus. MATERIALS AND METHODS This descriptive study of 94 erythromycin-resistant strains isolated from various clinical samples were subjected to D test as per CLSI guidelines. RESULTS Six (6.37%) isolates showed constitutive MLSв phenotype, 60 (63.82%) showed inducible MLSв phenotype, while 28 (29.78%) gave MS phenotype. Inducible resistance and MS phenotype was found to be higher in MRSA. CONCLUSION Percentage of inducible resistance and constitutive clindamycin resistance were higher among MRSA than MSSA. Clinical Laboratories should report inducible clindamycin resistance in S. aureus. Study showed that D test should be used as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance.
Authors and Affiliations
Vidya Shetty, Jyothirlatha Bangera, Shubha Parameshwaran
Keywords
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- EP ID EP417274
- DOI 10.14260/jemds/2018/495
- Views 72
- Downloads 0
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