Induction of Myocardial Infarction in Experimental Animals: A Review
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 11
Abstract
ABSTRACT Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved and efficacy of treatment. Although, it is difficult to create necrosis similar to those found in human heart, various large and small animals were used to create experimental model of MI. Each of these animals and method of selection offers various advantages and disadvantages in relation to clinical studies. In the present review, we aim to highlight the different methods used to induce MI in experimental animals. These methods may be beneficial for academicians and researchers concerned with the treatment of MI.
Authors and Affiliations
Syarifah Aisyah Syed Abd Halim, Norzana Abd Ghafar, Zakiah Jubri, Srijit Das
Keywords
Related Articles
- EP ID EP524312
- DOI 10.7860/JCDR/2018/36997.12221
- Views 81
- Downloads 0
Financial Burden of Out-of-Pocket Expenditures for Primary Health Care in Hilly Areas of Garhwal Region, Uttarakhand, North India
Introduction: High total health expenditures via Out-of-Pocket (OOP) as formal user fees and informal payments put India in challenging situation to achieve towards universal health coverage. Aim: To assess the (OOP) exp...
Intra- and Inter-operator Reproducibility Analysis of Automated Cloud-based Carotid Intima Media Thickness Ultrasound Measurement
ABSTRACT Introduction: Manual carotid intima media thickness (cIMT) measurements are tedious and prone to errors. Further, these measurements are subject to intra and inter-observer variability. Several studies affirm t...
Mott Cells: The Herculean Plasma cell
Images in Medicine
Pattern of Risk Factors and Correlates of Pruritus among Patients with Chronic Kidney Disease in Sokoto, Nigeria
Introduction: Chronic Kidney Disease (CKD) has become a major public health challenge globally. A cause for concern is the increasing burden of its risk factors, the complications of the disease, and their effects on the...
Expression of Angiogenic Factors in Psoriasis Vulgaris
Introduction: Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation, abnormal differentiation and inflammatory infiltration in the dermis. The dermal microvascular expansion assoc...