Infectious Disease Screening and Trends in Blood Donors in a Hospital based Blood Bank in Mumbai, Western India
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Despite reduction in risk of transfusion-transmitted infections (TTIs) during the past three decades, they still remain a serious complication of transfusion worldwide. The aim of the study was to assess the sero-prevalence and its relation to demographic profile of the blood donor population. Material and methods: This was a retrospective cross sectional study, which was carried out in the blood bank of Dr R N Cooper Hospital, Mumbai between January 2009 and June 2016. A total of 16899 blood donors were studied to determine the seroprevalence of Human immunodeficiency virus (HIV), Hepatitis C virus (HCV), Hepatitis B surface antigen (HBsAg), Malaria and Syphilis. A relation between seroprevalence to donor type (replacement donor versus voluntary donor), age and sex if any was studied. Result: The present study showed the sero-prevalence of HIV, HBV, HCV, syphilis and malaria was 0.6% (97/16899), 1.8% (302/16899), 0.7% (116/16899), 0.22% (38/16899) and 0.017%(3/16899), respectively. The TTI prevalence in replacement donors was 5.1%(49/947) as compared to voluntary donors i.e. 3.1%(510/15952). Highest prevalence of TTI (37.56%) was within the age group of 2635 years. There was a declining trend for HIV and HBV infection, which was statistically significant (P<0.005) while there was no significant change in the trend of seroprevalence of HCV infection. Conclusion: The current infectious disease pattern and trends in donor population can help in planning of future blood transfusion related health challenges. There is need for improvement and implementation of strict donor selection and sensitive screening tests which can minimize the risk of TTIs.
Authors and Affiliations
Fulzele Parag Prabhakar, Yasmeen Khatib, Akanksha Gaajre, Richa Patel, Arsala Mulla, Surekha Khaire
Keywords
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