Comparision of Lung Functions among Males and Females with Sickle Cell Anaemia
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 8
Abstract
Introduction: Sickle cell disorder has remained a neglected field of research in India and magnitude of problem has never been appreciated. Most of the reports spread a misconception that the sickle gene was confined to the tribal population. In India nearly 20 million people suffer from this disease. In it the red blood cells become deformed, rigid and obstruct the blood flow leading to tissue damage because of poor perfusion. The present study was undertaken to evaluate abnormalities in lung functions due to the disease. Material and Methods: The study was carried out in department of Physiology in association with department of Medicine at Government Medical College. The study protocol was approved by the ethical committee. The study included 200 subjects, out of which 100 were sickle cell disease patients and 100controlsin the age group of 20-35 yrs. FVC, FEV1, FEV1/FVC%, FEF 25-75%, PEFR and MVV values were chosen. All the variables were compared among the cases and controls by performing unpaired‘t’test.p value <0.05 was considered as statistically significant and <0.001 as highly significant. Results: All the PFT parameters were highly significantly reduced in cases,decline in the pulmonary function tests parameters in study group is suggestive of both restrictive and obstructive changes in sickle cell disease, restrictive pattern been more common. Conclusion: Most common abnormal pattern found was restrictive type. Pulmonary function testing can be a used as routine test to predict respiratory dysfunction in these patients.
Authors and Affiliations
Bageshree N Pande, V. D. Tajne
Keywords
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