Inflammation-related cancer or cancer-related inflammation
Journal Title: The European Research Journal - Year 2018, Vol 4, Issue 1
Abstract
Inflammation is the body’s defensive action against various stimuli such as physical or chemical or infectious agents. Acute inflammation and their mediators help in tissue repair and healing. If the inflammation aggravates chronically, non-resolved, dysregulated immune system, results release of various inflammatory mediators such as free radicals (ROS and RNS), cytokines, chemokines, growth factors and proteolytic enzymes produced by innate and adaptive immune cells activate transcriptional factors (NF-KB,STAT3 and HIF-1α) results in cell proliferation, angiogenesis, immunosuppression, genetic instability, invasion and metastasis. Oncogenes related to cancer activate inflammatory mediators such as chemokines and cytokines, which alters the inflammatory tumor microenvironment, promotes tumor progression. This article highlights about the role of inflammation and oncogenes activate inflammatory mediators in tumor progression.
Authors and Affiliations
Shrihari T. G
Keywords
Related Articles
- EP ID EP252485
- DOI 10.18621/eurj.312327
- Views 116
- Downloads 0
The diagnostic efficacy of clinical findings and electrophysiological studies in carpal tunnel syndrome
Objective. The aim of the study was to examine the relation between clinical findings, neurological examination and electrophysiological studies in diagnosing carpal tunnel syndrome (CTS) and share our institutional expe...
Silent cerebral embolism after carotid endarterectomy: a two-center experience
Objectives. Carotid endarterectomy (CEA) is considered the most effective treatment for stroke prevention in patients with critical carotid stenosis. The incidence of new ischemic lesions ranges from 0% to 33% at diffusi...
Fifteen-year treatment of metastatic thyroid medullary carcinoma: a case report
Although very rare, medullary thyroid carcinoma (MTC) is the most aggressive in differentiated thyroid malignancies. We report a 48-year-old male patient with the diagnosis of MTC, who was monitored for fifteen years and...
Impact of previous percutaneous coronary intervention on postoperative outcomes of coronary artery bypass grafting
Objective. The widespread use of percutaneous coronary intervention (PCI) has resulted in an increasing number of patients who have undergone prior PCI being referred for coronary artery bypass grafting (CABG). The aim o...
Balo’s concentric sclerosis: a case report
Balo’s concentric sclerosis is a rare variant of multiple sclerosis which is characterized by lesions consisting rings of demyelination alternating with areas of relatively preserved myelin. These pathological changes ar...